an N-acylsphinganine-1-phosphocholine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

196 compounds within 3 steps: 2 in 1, 33 in 2, 161 in 3

Three steps

dodecanoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
eicosanoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
tetradecanoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
octadecanoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
a 1-acylglycerone 3-phosphateReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA
Catalysed by SGMS1, SGMS2, LPGAT1, GNPAT
an N-acylglycineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by SGMS1, SGMS2, LPGAT1, GLYATL3 and 2 more
an N-acylsphing-4-enine 1-phosphateReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. delta 4-desaturase, sphingolipid (dihydroceramide pool)
3. an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)
Catalysed by SGMS1, SGMS2, DEGS1, DEGS2 and 2 morecytosol
sphing-4-enineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. delta 4-desaturase, sphingolipid (dihydroceramide pool)
3. acyl-CoA:sphingosine N-acyltransferase
Catalysed by SGMS1, SGMS2, DEGS1, DEGS2 and 4 morecytosol, Golgi apparatusOne of 4 routes
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by SGMS1, SGMS2, LPGAT1, LCLAT1 and 1 moreOne of 5 routes
sphinganine 1-phosphateReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. N-acylsphingosine amidohydrolase
3. ATP:sphinganine 1-phosphotransferase
Catalysed by SGMS1, SGMS2, ASAH1, ACER2 and 6 morecytosolOne of 3 routes
a 1-acyl-sn-glycero-3-phosphateReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
Catalysed by SGMS1, SGMS2, LPGAT1, GPAT3 and 3 moreOne of 3 routes
a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
3. a 1-acyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SGMS1, SGMS2, PLA2G10, PLA2G6 and 29 more
a CDP-1,2-diacyl-sn-glycerolReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
3. a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate
Catalysed by SGMS1, SGMS2, PLD2, PLD1 and 4 moreOne of 2 routes
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)Reach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
Catalysed by SGMS1, SGMS2, OSBPL3, PIP5K1B and 2 moreinner side of the membrane, outer side of the membrane
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. N-acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by SGMS1, SGMS2, ASAH1, ACER2 and 3 morecytosol, extracellular spaceOne of 12 routes
CDP-cholineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)
3. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
Catalysed by SGMS1, SGMS2, SMPD1, PCYT1A and 1 moreOne of 2 routes
1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
3. (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SGMS1, SGMS2, PLA2G10, PLA2G6 and 29 more
(9Z)-hexadecenoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
CHEBI:63544Reach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
(4R)-hydroxysphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
3. Phytoceramide amidohydrolase
Catalysed by SGMS1, SGMS2, DEGS1, DEGS2 and 5 morecytosolOne of 2 routes
a 1-acyl-sn-glycero-3-phospho-L-serineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline
3. a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine
Catalysed by SGMS1, SGMS2, PTDSS1, PLA2G15
a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
3. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
Catalysed by SGMS1, SGMS2, SAMD8, SELENOI and 1 moreOne of 4 routes
a triacyl-sn-glycerolReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA
Catalysed by SGMS1, SGMS2, SAMD8, DGAT1 and 5 moreOne of 2 routes
a 1-acyl-sn-glycerolReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
3. a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H(+)
Catalysed by SGMS1, SGMS2, PLA2G10, PLA2G6 and 29 more
a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SGMS1, SGMS2, LPGAT1, LCLAT1 and 2 moreOne of 4 routes
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerolReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by SGMS1, SGMS2, PLA2G10, PLA2G6 and 29 moreOne of 3 routes
hexacosanoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
a 2-acyl-sn-glycerol 3-phosphateReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
Catalysed by SGMS1, SGMS2, LPGAT1, ENPP2One of 2 routes
tetracosanoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
docosanoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
N-hexadecanoyl-(4R)-hydroxysphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by SGMS1, SGMS2, SAMD8One of 2 routes
a 2-acyl-sn-glycero-3-phospho-L-serineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline
3. a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
Catalysed by SGMS1, SGMS2, PTDSS1, PLA1A and 2 moreOne of 2 routes
N-docosanoylsphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
3. docosanoyl-CoA + sphinganine = N-docosanoylsphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ACER2, ACER1 and 4 more
N-(2-hydroxydocosanoyl)-sphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
3. 2-hydroxydocosanoyl-CoA + sphinganine = N-(2-hydroxydocosanoyl)-sphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ACER2, ACER1 and 3 more
N-eicosanoylsphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
3. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ACER2, ACER1 and 4 more
N-(octadecanoyl)-sphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
3. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ACER2, ACER1 and 7 more
N-(2-hydroxyoctadecanoyl)-sphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
3. 2-hydroxyoctadecanoyl-CoA + sphinganine = N-(2-hydroxyoctadecanoyl)-sphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ACER2, ACER1 and 3 more
N-hexadecanoylsphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
3. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ACER2, ACER1 and 4 moreOne of 3 routes
N-(2-hydroxyhexadecanoyl)-sphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
3. 2-hydroxyhexadecanoyl-CoA + sphinganine = N-(2-hydroxyhexadecanoyl)-sphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ACER2, ACER1 and 2 more
N-(tetradecanoyl)-sphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
3. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ACER2, ACER1 and 3 more
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
(8Z,11Z,14Z)-eicosatrienoateReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. N-acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by SGMS1, SGMS2, ASAH1, ACER2 and 3 morecytosol, extracellular spaceOne of 12 routes
N-(octacosanoyl)-sphinganineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
3. octacosanoyl-CoA + sphinganine = N-(octacosanoyl)-sphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ACER2, ACER1 and 2 more
1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
Catalysed by SGMS1, SGMS2
an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. delta 4-desaturase, sphingolipid (dihydroceramide pool)
3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by SGMS1, SGMS2, DEGS1, DEGS2 and 1 morecytosol
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
(9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
(13Z)-docosenoyl-CoAReach from here →
1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol