N(1),N(12)-diacetylspermine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

159 compounds within 3 steps: 4 in 1, 6 in 2, 149 in 3

Three steps

taurocyamineReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. taurine + L-arginine = taurocyamine + L-ornithine
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 1 morecytosol, extracellular space
L-phenylalanineReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. transport of arginine and phenylalanine (cytosol to extracellular)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6cytosol, extracellular spaceOne of 4 routes
L,L-cystathionineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
Catalysed by NAGScytosol, mitochondrial matrix
N-acetylputrescineReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)
3. acetyl-CoA:putrescine N-acetyltransferase
Catalysed by PAOX, SMOX, SAT1, SAT2cytosolOne of 2 routes
4-aminobutanalReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)
3. putrescine + O2 + H2O = 4-aminobutanal + H2O2 + NH4(+)
Catalysed by PAOX, SMOX, AOC1cytosol
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 1 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes
an acyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. acyl-CoA:sphingosine N-acyltransferase
Catalysed by ASAH1, ACER2, ACER1, ASAH2cytosol, Golgi apparatusOne of 2 routes
3-aminopropanalReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. diamine N-acetyltransferase (N1-acetylspermine)
3. spermidine:oxygen oxidoreductase (spermidine-forming)
Catalysed by SAT1, SAT2, SMOXcytosol
5-guanidino-2-oxopentanoateReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 1 morecytosol, extracellular space
N(8)-acetylspermidineReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
3. N8-acetylspermidine to spermidine conversion
Catalysed by PAOX, SMOXcytosolOne of 3 routes
(3Z)-dodecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)
Catalysed by HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)
Catalysed by SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes
deoxycholoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
Catalysed by SLC27A2, SLC27A5cytosolOne of 4 routes
decanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. medium-chain acyl-CoA ligase (decanoic acid)
Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 7 routes
(2E)-hexadecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Carnitine O-Palmitoyltransferase
Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes
(9Z)-hexadecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (palmitolate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 11 routes
3-hydroxyisovaleryl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)
Catalysed by CPT1A, CPT1Bcytosol
CHEBI:63544Reach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (adrenic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes
hexacosanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (cerotic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
tetracosanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (lignocerate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 10 routes
docosanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (behenic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes
N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
1. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
2. Transport by Y+Lat-2 into Extracellular Space
3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)
Catalysed by PAOX, SMOX, SLC3A2, SLC7A6 and 3 morecytosol, extracellular space
(2E)-octadecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Carnitine O-Palmitoyltransferase
Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (stearidonic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 8 routes
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (EPA)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (DPA)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes
(9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (linolenate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes
(13Z)-docosenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes
(11Z)-eicosenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 4 routes
(15Z)-tetracosenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (nervonic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes
(17Z)-hexacosenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (ximenic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 4 routes
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
nonadecanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes
dodecanedioyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Activation of dodecanedioic acid
No catalyst recordedcytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Production of Sebacoylcarnitine
Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Production of Suberylcarnitine
Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Activation of adipic acid for Formation of Adipoyl Carnitine
No catalyst recordedcytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by CPT1A, CPT1C, CPT1Bcytosol
(13Z)-eicosenoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. N1,N12-diacetylspermine to N1-acetylspermine conversion
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by CRAT, CROTcytosol, peroxisomeOne of 3 routes