Proteins/UNIPROT:Q96PH1

NOX5

ProteinUNIPROT:Q96PH1NADPH oxidase 5

Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Also synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation. May play a role in cell growth and apoptosis..

[Isoform v2]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contributes to endothelial response to thrombin. Regulates redox-dependent processes in lymphocytes and spermatozoa..

[Isoform v1]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor..

[Isoform v5]: This isoform lacks calcium-binding domains and was showed to present a NADPH oxidase activity in a calcium-independent manner. May be involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. However another study showed an absence of oxidase activity. Subject to rapid degradation..

[Isoform v3]: Lacks calcium-dependent NADPH oxidase activity..

[Isoform v4]: Lacks calcium-dependent NADPH oxidase activity..

Function from UniProtKB (Q96PH1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 6 reference databases · Subject: NOX5 · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways

Order

SUMO1 interacts with NOX5ProteinHetionet hetionet:interacts:7341-79400Inferred only
UBC interacts with NOX5ProteinHetionet hetionet:interacts:7316-79400Inferred only
NOX5 participates in Cellular response to chemical stressPathwayReactome R-HSA-9711123Inferred only
NOX5 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
NOX5 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
NOX5 participates in Detoxification of Reactive Oxygen SpeciesPathwayReactome R-HSA-3299685Inferred only
NOX5 participates in Oxidative stress responsePathwayWikiPathways WP408Inferred only
NOX5 regulates positive regulation of cytokine productionBiological processgene ontology Q96PH1|GO:0001819Inferred only
NOX5 regulates positive regulation of reactive oxygen species metabolic processBiological processgene ontology Q96PH1|GO:2000379Inferred only
NOX5 regulates regulation of fusion of sperm to egg plasma membraneBiological processgene ontology Q96PH1|GO:0043012Inferred only
NOX5 requires the cofactor FAD(3-)CompoundUniProt Q96PH1Inferred only
NOX5 requires the cofactor magnesium(2+)CompoundUniProt Q96PH1Inferred only

Show the remaining 4

NAADP(+) is a substrate of NOX5CompoundRhea RHEA:86239Inferred only
NAADPH is a substrate of NOX5CompoundRhea RHEA:86239Inferred only
superoxide is a substrate of NOX5CompoundRhea RHEA:63180Inferred only
superoxide is a substrate of NOX5CompoundRhea RHEA:86239Inferred only

Reactions

2 reactions

NADPH(4-)+2dioxygen2superoxide+NADP(3-)+hydron
Catalysed by CYBB or NOX5 or NOX3 or NOX4 or NOX1
Reaction pageDirection not assertedBalanced
Rhea RHEA:63180CC BY 4.0Reference data
NAADPH+2dioxygenNAADP(+)+

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