sphinganine 1-phosphate

Three steps

• CHEBI:16132Reach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. ethanolamine-phosphate phosphate-lyase (deaminating
  3. deoxyribose-phosphate aldolase

  Catalysed by SGPL1, ETNPPL, DERAendoplasmic reticulum, cytosol

• 11-cis-retinolReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 10 morecytosol

• oxaloacetateReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. ATP citrate lyase (citrate)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 6 morecytosol

• anilineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 7 morecytosol

• CHEBI:17312Reach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 5 morecytosolOne of 2 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. CTP:ethanolamine-phosphate cytidylyltransferase
  3. ethanolaminephosphotransferase (1-alkenyl-2-acylglycerol)

  Catalysed by SGPL1, PCYT2, SELENOI, CEPT1endoplasmic reticulum, cytosol

• L-cysteineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 6 morecytosol, mitochondrial matrix

• all-trans-retinyl hexadecanoateReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by SGPL1, ALDH3B1, ALDH3B2, ALDH3A2 and 1 moreendoplasmic reticulum

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycerolReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 7 morecytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 5 morecytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 8 routes

• S-hexadecanoyl-N-acetylcysteamineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
  3. S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)

  Catalysed by SGPL1, ALDH3B1, ALDH3B2, ALDH3A2 and 2 moreendoplasmic reticulum

• S-hexadecanoyl-N-acetylcysteine methyl esterReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
  3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

  Catalysed by SGPL1, ALDH3B1, ALDH3B2, ALDH3A2 and 1 moreendoplasmic reticulum

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• octadecanoateReach from here →
  1. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  2. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)
  3. N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate

  Catalysed by SGPP2, SGPP1, CERS1, CERS6 and 5 more

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. Phosphoethanolamine phosphohydrolase
  3. fatty acylamide amidohydrolase

  Catalysed by SGPL1, PHOSPHO1, FAAHendoplasmic reticulum, cytosol

• CHEBI:27540Reach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 11 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, peroxisomeOne of 7 routes

• a fatty acidReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. an N-acylsphinganine + H2O = sphinganine + a fatty acid

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol

• acetateReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. ethanolamine-phosphate phosphate-lyase (deaminating
  3. Acetaldehyde:NAD+ oxidoreductase

  Catalysed by SGPL1, ETNPPL, ALDH3A1, ALDH3B1 and 2 moreendoplasmic reticulum, cytosolOne of 4 routes

• (9Z)-octadecenoateReach from here →
  1. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  2. sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)
  3. H2O[r] + N-(9Z-octadecenoyl)-sphinganine[r] = oleate[r] + sphinganine[r]

  Catalysed by SGPP2, SGPP1, CERS5, CERS2 and 1 moreendoplasmic reticulumOne of 2 routes

• an N-acyl-(4R)-4-hydroxysphinganineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 7 morecytosolOne of 2 routes

• fatty acidReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. N-acylsphingosine amidohydrolase

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 10 morecytosol

• taurineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 6 morecytosolOne of 2 routes

• an N-acylsphing-4-enineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. delta 4-desaturase, sphingolipid (dihydroceramide pool)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 7 morecytosolOne of 5 routes

• 16-hydroxyhexadecanoateReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
  3. hexadecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxyhexadecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SGPL1, ALDH3B1, ALDH3B2, ALDH3A2 and 3 moreendoplasmic reticulum

• glycineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 5 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 6 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 7 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 11 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Production of Glutaryl Carnitine

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosolOne of 2 routes

• hexadecanoyl-CoAReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
  3. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate

  Catalysed by SGPL1, ALDH3B1, ALDH3B2, ALDH3A2 and 11 moreendoplasmic reticulum

• eicosanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 6 morecytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. phytanate-CoA ligase

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 5 morecytosolOne of 5 routes