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Reach

(9Z)-octadecenoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

652 compounds within 3 steps: 78 in 1, 124 in 2, 450 in 3

Does it reach a compound?

One step

1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by LCLAT1
1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by LCLAT1
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by LCLAT1, LPGAT1
1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by LCLAT1
1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. a 1-acyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by LPCAT4
1-dodecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-dodecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by MOGAT2, MOGAT1
1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-tetradecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by MOGAT2, MOGAT1
1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-hexadecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by MOGAT2, MOGAT1
1-octadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-octadecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by MOGAT2
1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by MOGAT2, MOGAT1
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by MOGAT2, MOGAT1
1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-(9Z,12Z-octadecadienoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by MOGAT2, MOGAT1
decyl (9Z)-octadecenoateReach from here →
1. decan-1-ol + (9Z)-octadecenoyl-CoA = decyl (9Z)-octadecenoate + CoA
Catalysed by AWAT1
hexadecyl (9Z)-octadecenoateReach from here →
1. hexadecan-1-ol + (9Z)-octadecenoyl-CoA = hexadecyl (9Z)-octadecenoate + CoA
Catalysed by AWAT1, AWAT2
1-O-(9Z)-hexadecenyl (9Z)-octadecenoateReach from here →
1. (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA
Catalysed by AWAT1, AWAT2
octadecyl (9Z)-octadecenoateReach from here →
1. octadecan-1-ol + (9Z)-octadecenoyl-CoA = octadecyl (9Z)-octadecenoate + CoA
Catalysed by AWAT1, AWAT2
1-O-(9Z)-octadecenyl (9Z)-octadecenoateReach from here →
1. (9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA
Catalysed by AWAT1, AWAT2
1-O-eicosanyl (9Z)-octadecenoateReach from here →
1. eicosan-1-ol + (9Z)-octadecenoyl-CoA = 1-O-eicosanyl (9Z)-octadecenoate + CoA
Catalysed by AWAT1
1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerolReach from here →
1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA
Catalysed by DGAT1
1,3-di-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,3-di-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by MOGAT2, MOGAT1
1-(9Z-octadecenoyl)-3-hexadecanoylglycerolReach from here →
1. 1-hexadecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-3-hexadecanoylglycerol + CoA
Catalysed by MOGAT2, MOGAT1
1-O-hexadecyl-3-(9Z)-octadecenoylglycerolReach from here →
1. 1-O-hexadecylglycerol + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol + CoA
Catalysed by MOGAT2
1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by LPCAT4, MBOAT1, MBOAT2
1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by MBOAT2
(2E,9Z)-octadecadienoyl-CoAReach from here →
1. oxidized [electron-transfer flavoprotein] + (9Z)-octadecenoyl-CoA + H(+) = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
Catalysed by ACADL, ACADVL, ACAD9One of 2 routes
1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerolReach from here →
1. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by HADHA
O-(9Z)-octadecenoyl-(R)-carnitineReach from here →
1. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
Catalysed by CPT2
1-decanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. 1-decanoylglycerol + (9Z)-octadecenoyl-CoA = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by MOGAT2

Two steps

(S)-carnitineReach from here →
1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
2. Utilized Transport
Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 moreendoplasmic reticulum, cytosolOne of 2 routes
CHEBI:1146900Reach from here →
1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. Stearoyl-CoA hydrolase
Catalysed by SCD, SCD5, ACOT7, BAAT and 3 more

Page 2 of 14

cytosol

One of 11 routes

CHEBI:1307929Reach from here →

cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
Steryl-ester acylhydrolase

Catalysed by SOAT2, SOAT1, CEL, LIPAlysosomeOne of 2 routes

N-(9Z-octadecenoyl)-L-phenylalanineReach from here →

(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 5 more

N-(9Z-octadecenoyl)-L-leucineReach from here →

(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 5 more

N-octadecanoylglycineReach from here →

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

Catalysed by SCD, SCD5, GLYATL2

9-(9Z-octadecenoyloxy)-octadecanoateReach from here →

2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA
9-hydroxy-octadecanoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 9-(9Z-octadecenoyloxy)-octadecanoate + 2-(9Z-octadecenoyl)-glycerol

Catalysed by DGAT1, MOGAT3, DGAT2, PNPLA2One of 2 routes

1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →

sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

Catalysed by GPAT3, GPAT4, GPAM, AGPAT4

2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →

1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoate + H(+)

Catalysed by LCLAT1, LPGAT1, PLA2G15, DDHD1One of 2 routes

N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →

(9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by GLYATL3, GLYATL2, PAM

an N-octadecanoyl-sphingoid baseReach from here →

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)

Catalysed by SCD, SCD5, CERS1

(7Z)-octadecenoyl-CoAReach from here →

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
stearoyl-CoA 9-desaturase (stearoyl-CoA)

Catalysed by SCD, SCD5cytosol

palmitoyl-CoAReach from here →

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Beta Oxidation of Long Chain Fatty Acid

Catalysed by SCD, SCD5, ACAA1, HSD17B4 and 2 moreperoxisome

oleoyl-CoAReach from here →

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)

Catalysed by SCD, SCD5cytosolOne of 6 routes

cholesterolReach from here →

cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)

Catalysed by SOAT2, SOAT1, CEL, CES1 and 3 more

(R)-carnitineReach from here →

(R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
(R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA

Catalysed by CPT2

CHEBI:16566Reach from here →

sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)
H2O[r] + N-(9Z-octadecenoyl)-sphinganine[r] = oleate[r] + sphinganine[r]

Catalysed by CERS5, CERS2, ACER3endoplasmic reticulumOne of 2 routes

a cholesterol esterReach from here →

cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

Catalysed by SOAT2, SOAT1endoplasmic reticulumOne of 3 routes

N-octadecanoyl-heptadecasphing-4-enineReach from here →

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

Catalysed by SCD, SCD5, CERS1

glycerolReach from here →

1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
1-(9Z-octadecenoyl)-glycerol + 1,2-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol

Catalysed by DGAT1, MOGAT2, AWAT2, DGAT2L6 and 5 moreOne of 2 routes

1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

Catalysed by SCD, SCD5, LPGAT1

octadecanoateReach from here →

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Stearoyl-CoA hydrolase

Catalysed by SCD, SCD5, ACOT7, BAAT and 3 morecytosolOne of 5 routes