a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

249 compounds within 3 steps: 6 in 1, 43 in 2, 200 in 3

Three steps

11-cis-retinyl esterReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA
Catalysed by ASAH1, ACSL3, AWAT2
13-cis-retinyl esterReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
3. 13-cis-retinol + a fatty acyl-CoA = 13-cis-retinyl ester + CoA
Catalysed by ASAH1, ACSL3, AWAT2
9-cis-retinyl esterReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
3. 9-cis-retinol + a fatty acyl-CoA = 9-cis-retinyl ester + CoA
Catalysed by ASAH1, ACSL3, AWAT2
a lysoGb3(d18:1(4E))Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
2. alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)
3. a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
Catalysed by B4GALT5, B4GALT6, A4GALT, ASAH1cytosol
(11Z)-docosenoyl-CoA(4-)Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
(7Z)-tetradecenoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
a long-chain alcohol wax esterReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
3. a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA
Catalysed by ASAH1, ACSL3, AWAT1, AWAT2
NAADPHReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
3. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
Catalysed by GBA1, GBA3, GBA2, ADPGK and 1 more
docosanoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
octadecanoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
alpha-linolenic acidReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
beta-D-galactoseReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)
3. lactose + H2O = beta-D-galactose + D-glucose
Catalysed by GBA1, GBA3, GBA2, B4GALT2 and 2 moreOne of 3 routes
a ganglioside GA1 (d18:1(4E))Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
2. beta-1,4-N-acetyl-galactosaminyltransferase (LacCer pool)
3. a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GA1 (d18:1(4E)) + UDP + H(+)
Catalysed by B4GALT5, B4GALT6, B4GALNT1, B3GALT4cytosol
elaidic acidReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosolOne of 13 routes
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
beta-D-fructoseReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. Aldehyde Reductase
3. D-Glucitol:NAD+ 2-oxidoreductase
Catalysed by GBA1, GBA3, GBA2, SORDcytosol
phosphocholineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. ceramide:phosphatidylcholine cholinephosphotransferase
3. a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)
Catalysed by GBA1, GBA3, GBA2, SGMS1 and 6 moreGolgi apparatus
tetradecanoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
(9Z)-octadecenoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
hexacosanoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
tetracosanoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
an N-acylsphinganineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. sphingosine N-acyltransferase (sphinganine)
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 9 moreGolgi apparatus, cytosolOne of 4 routes
an N-acyl-(4R)-4-hydroxysphinganineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. ceramide:phosphatidylcholine cholinephosphotransferase
3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by GBA1, GBA3, GBA2, SGMS1 and 1 moreGolgi apparatus
eicosanoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
(9Z)-hexadecenoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
(15Z)-tetracosenoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
(11Z)-eicosenoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
(24S)-hydroxycholesterolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by GBA1, GBA3, GBA2, CYP46A1
N-acetylneuraminateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
2. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
3. a ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate
Catalysed by B4GALT5, B4GALT6, ST3GAL5, NEU4 and 1 morecytosol
cholesteryl hexadecanoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA
Catalysed by GBA1, GBA3, GBA2, SOAT1
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 7 moreGolgi apparatus, cytosol
sphingosine 1-phosphateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. ATP:sphingosine 1-phosphotransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 6 moreGolgi apparatus, cytosolOne of 2 routes
D-galactoseReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
Catalysed by GBA1, GBA3, GBA2, UGT8 and 1 moreOne of 2 routes
cholesteryl (9Z,12Z)-octadecadienoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. (9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA
Catalysed by GBA1, GBA3, GBA2, SOAT1One of 2 routes
25-hydroxycholesterolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Catalysed by GBA1, GBA3, GBA2, CH25HOne of 3 routes
N-acetyl-beta-neuraminic acidReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
2. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
3. exo-alpha-sialidase (GM3)
Catalysed by B4GALT5, B4GALT6, ST3GAL5, NEU4 and 3 morecytosolOne of 4 routes
N-octanoylsphing-4-enineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by GBA1, GBA3, GBA2One of 2 routes
cholesteryl (9Z-octadecenoate)Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
Catalysed by GBA1, GBA3, GBA2, SOAT2 and 1 moreOne of 2 routes
N-(acetyl)-sphing-4-enineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 4 moreGolgi apparatusOne of 2 routes
a 1,3-diacylglycerolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 5 moreGolgi apparatus
keto-D-fructoseReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. Aldehyde Reductase
3. keto-D-fructose + NADH + H(+) = D-sorbitol + NAD(+)
Catalysed by GBA1, GBA3, GBA2, SORDcytosol
a 1,2-diacylglycerolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 8 moreGolgi apparatusOne of 2 routes
(24R)-hydroxycholesterolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24R)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by GBA1, GBA3, GBA2, CYP3A4
a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 6 moreGolgi apparatus
(6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
dodecanoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
eicosanoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
tetradecanoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol