a triacylglycerol

Three steps

• a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
  1. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
  2. a 1,2-diacylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a triacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  3. a 1-acyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LIPA, PNPLA4, LIPN, PNPLA2 and 2 more

• a CDP-1,2-diacyl-sn-glycerolReach from here →
  1. triacylglycerol acylhydrolase
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate

  Catalysed by LPL, DGKI, DGKA, DGKG and 11 moreextracellular space

• an acyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 6 moreextracellular space, cytosol, Golgi apparatusOne of 6 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 4 moreextracellular space, cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 4 moreextracellular space, cytosolOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by LPL, FAAH, PM20D1extracellular space

• 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
  1. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
  2. a 1,2-diacylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a triacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  3. (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LIPA, PNPLA4, LIPN, PNPLA2 and 2 more

• (9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. linoleate:oxygen 9-oxidoreductase

  Catalysed by LPLextracellular space, cytosol

• decanoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 8 moreextracellular space, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosolOne of 6 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 16 routes

• a cardiolipinReach from here →
  1. triacylglycerol acylhydrolase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by LPL, SGMS1, SGMS2, TAFAZZINextracellular space

• an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. triacylglycerol acylhydrolase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by LPL, SGMS1, SGMS2, PLA2G4E and 2 moreextracellular spaceOne of 4 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 4 moreextracellular space, cytosol

• CHEBI:63544Reach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 9 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. cytochrome P450 (arachidonate)

  Catalysed by LPL, CYP4F8extracellular space, endoplasmic reticulumOne of 2 routes

• (4R)-hydroxysphinganineReach from here →
  1. triacylglycerol acylhydrolase
  2. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol
  3. Phytoceramide amidohydrolase

  Catalysed by LPL, SGMS1, SGMS2, ASAH1 and 4 moreextracellular space, cytosolOne of 2 routes

• a 1-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. triacylglycerol acylhydrolase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine

  Catalysed by LPL, SELENOI, CEPT1, PLA2G15extracellular spaceOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamineReach from here →
  1. triacylglycerol acylhydrolase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)

  Catalysed by LPL, SELENOI, CEPT1, PEMTextracellular space

• a 1-acyl-sn-glycerolReach from here →
  1. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
  2. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
  3. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)

  Catalysed by DDHD2, LPL, LIPF, ABHD2 and 16 moreOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. triacylglycerol acylhydrolase
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate

  Catalysed by LPL, DGKI, DGKA, DGKG and 9 moreextracellular space

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
  2. a 1,2-diacylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a triacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by LIPA, PNPLA4, LIPN, PNPLA2 and 2 more

• hexacosanoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 8 routes

• a 2-acyl-sn-glycerol 3-phosphateReach from here →
  1. triacylglycerol acylhydrolase
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)

  Catalysed by LPL, DGKI, DGKA, DGKG and 9 moreextracellular spaceOne of 2 routes

• tetracosanoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 16 routes

• docosanoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 13 routes

• a 2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. triacylglycerol acylhydrolase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)

  Catalysed by LPL, SELENOI, CEPT1, DDHD1extracellular spaceOne of 2 routes

• an N-acylsphinganine-1-phosphocholineReach from here →
  1. triacylglycerol acylhydrolase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by LPL, SGMS1, SGMS2extracellular spaceOne of 2 routes

• all-trans-retinyl 9Z-octadecenoateReach from here →
  1. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
  2. carboxylesterase (retinyl-ester)
  3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol

  Catalysed by PNPLA4, PNPLA2, CES2, RBP4 and 16 morecytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosolOne of 4 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 8 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)

  Catalysed by LPL, ABHD12extracellular space

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)

  Catalysed by LPL, ABHD16Aextracellular space

• N-dodecanoylsphing-4-enineReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by LPL, NAAA, ASAH1, ACER2 and 1 moreextracellular space

• N-tetradecanoylsphing-4-enineReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate

  Catalysed by LPL, ASAH1, ACER2, ASAH2extracellular space

• N-octadecanoylsphing-4-enineReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate

  Catalysed by LPL, ASAH1, ACER2, ASAH2extracellular space

• an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
  1. triacylglycerol acylhydrolase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by LPL, SGMS1, SGMS2, SAMD8extracellular spaceOne of 2 routes

• (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (7Z,10Z,13Z,16Z)-docosatetraenoate + ATP + CoA = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by LPL, ACSL4extracellular space

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
  2. a 1-acylglycerol + a 1,2-diacylglycerol = a triacylglycerol + glycerol
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LIPA, PNPLA4, LIPN, PNPLA2 and 2 moreOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 12 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 8 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 9 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 9 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 8 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 6 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 7 routes