a monoacylglycerol

Three steps

• dihydroxyacetone phosphateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)
  3. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)

  Catalysed by LIPE, GK, GK3, GK2 and 3 moreOne of 2 routes

• sphing-4-enineReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 10 morecytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• sphinganineReach from here →
  1. 1-acylglycerol acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + H2O = sphinganine + a fatty acid

  Catalysed by ABHD12, MGLL, ABHD6, ASAH1 and 4 morecytosol

• spermidineReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 8 morecytosol, mitochondrial matrixOne of 3 routes

• L-methionineReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 7 morecytosol, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by LIPE, GK, GK3, GK2 and 5 more

• L-alanineReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 6 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 7 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 7 morecytosol, mitochondrial matrix

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)

  Catalysed by AGK, DHRS7Bcytosol

• CDP-glycerolReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)
  3. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)

  Catalysed by LIPE, GK, GK3, GK2 and 2 more

• an acyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. acyl-CoA pool formation and breakdown

  Catalysed by ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 3 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 9 morecytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 8 morecytosol, mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 8 morecytosol, mitochondrial matrixOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by ABHD12, MGLL, ABHD6, FAAH and 1 morecytosol, extracellular space

• D-glyceraldehyde 3-phosphateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  3. D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)

  Catalysed by LIPE, AKR1A1, AKR1B1, TKFC

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate)Reach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)
  3. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)

  Catalysed by LIPE, GK, GK3, GK2 and 2 more

• (9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. linoleate:oxygen 9-oxidoreductase

  Catalysed by ABHD12, MGLL, ABHD6cytosol, extracellular space

• decanoyl-CoAReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 12 morecytosol, mitochondrial matrixOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Long-Chain-Fatty-Acid-Coa Ligase

  Catalysed by ABHD12, MGLL, ABHD6, SLC27A2 and 6 morecytosol, extracellular space, endoplasmic reticulumOne of 6 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ABHD12, MGLL, ABHD6, SLC27A2 and 7 morecytosol, extracellular spaceOne of 16 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 8 morecytosol, mitochondrial matrix

• CHEBI:63544Reach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ABHD12, MGLL, ABHD6, SLC27A2 and 7 morecytosol, extracellular spaceOne of 9 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. cytochrome P450 (arachidonate)

  Catalysed by ABHD12, MGLL, ABHD6, CYP4F8cytosol, extracellular space, endoplasmic reticulumOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LIPE, ACSL3, LPGAT1

• a 1-acyl-sn-glycerolReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
  3. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)

  Catalysed by LIPE, ABHD11

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by AGK, AGPAT2, GPAT3, LCLAT1 and 6 morecytosol

• hexacosanoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ABHD12, MGLL, ABHD6, SLC27A2 and 7 morecytosol, extracellular spaceOne of 8 routes

• tetracosanoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ABHD12, MGLL, ABHD6, SLC27A2 and 7 morecytosol, extracellular spaceOne of 16 routes

• docosanoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ABHD12, MGLL, ABHD6, SLC27A2 and 7 morecytosol, extracellular spaceOne of 13 routes

• an N-acylsphinganine-1-phosphocholineReach from here →
  1. 1-acylglycerol acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by ABHD12, MGLL, ABHD6, ASAH1 and 6 morecytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. fatty-acid-CoA ligase

  Catalysed by ABHD12, MGLL, ABHD6, ACSL1cytosol, extracellular spaceOne of 4 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 14 morecytosol, mitochondrial matrixOne of 8 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)

  Catalysed by ABHD12, MGLL, ABHD6cytosol, extracellular space

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)

  Catalysed by ABHD12, MGLL, ABHD6, ABHD16Acytosol, extracellular space

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGK, AGPAT2cytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGK, AGPAT2cytosol

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGK, AGPAT2cytosol

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by AGK, AGPAT2, AGPAT3cytosol

• N-dodecanoylsphing-4-enineReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by ABHD12, MGLL, ABHD6, NAAA and 3 morecytosol, extracellular space

• N-tetradecanoylsphing-4-enineReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate

  Catalysed by ABHD12, MGLL, ABHD6, ASAH1 and 2 morecytosol, extracellular space

• N-octadecanoylsphing-4-enineReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate

  Catalysed by ABHD12, MGLL, ABHD6, ASAH1 and 2 morecytosol, extracellular space

• a 1-O-alkylglycerone 3-phosphateReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. aldo-keto reductase (1-acylglycerol-3P pool)
  3. alkylglycerone phosphate synthase (acylglycerone-phosphate)

  Catalysed by AGK, AKR1A1, AGPScytosol, peroxisome

• (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (7Z,10Z,13Z,16Z)-docosatetraenoate + ATP + CoA = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by ABHD12, MGLL, ABHD6, ACSL4cytosol, extracellular space

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ABHD12, MGLL, ABHD6, SLC27A2 and 7 morecytosol, extracellular spaceOne of 12 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ABHD12, MGLL, ABHD6, SLC27A2 and 7 morecytosol, extracellular spaceOne of 8 routes

• 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

  Catalysed by AGK, MBOAT2cytosol

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. 1-acylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ABHD12, MGLL, ABHD6, SLC27A2 and 7 morecytosol, extracellular spaceOne of 9 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. ATP:acylglycerol 3-phosphotransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 14 morecytosol, mitochondrial matrixOne of 6 routes