CHEBI:17202

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

76 compounds within 3 steps: 4 in 1, 15 in 2, 57 in 3

Three steps

Asp-tRNA(Asp)Reach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)
Catalysed by ADSS2, ADSS1, DARS1cytosol
N-carbamoyl-L-aspartateReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)
Catalysed by ADSS2, ADSS1, CADcytosol
thiosulfateReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
3. transport of fumarate and thiosulfate (cytosol to mitochondria)
Catalysed by ADSS2, ADSS1, ADSL, TNRC6B and 1 morecytosol, mitochondrial matrixOne of 2 routes
2-deoxy-alpha-D-ribose 1-phosphateReach from here →
1. inosine 5'-monophosphate phosphohydrolase
2. dIMP + inosine = 2'-deoxyinosine + IMP
3. 2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
Catalysed by ACP3, NT5E, NT5C2, NT5C and 4 morecytosolOne of 2 routes
7,8-dihydrofolateReach from here →
1. IMP 1,2-hydrolase (decyclizing)
2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
3. 10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate
Catalysed by ATICcytosol
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. IMP 1,2-hydrolase (decyclizing)
2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
3. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate
Catalysed by ATICcytosol
(6R)-5,10-methenyltetrahydrofolateReach from here →
1. IMP 1,2-hydrolase (decyclizing)
2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
3. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)
Catalysed by ATIC, MTHFD1cytosolOne of 2 routes
2-(N(omega)-L-arginino)succinateReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
Catalysed by ADSS2, ADSS1, ADSL, TNRC6B and 1 morecytosolOne of 4 routes
dGMPReach from here →
1. IMP:NAD+ oxidoreductase
2. IMP + NAD(+) + H2O = XMP + NADH + H(+)
3. dGMP + inosine = 2'-deoxyguanosine + IMP
Catalysed by IMPDH2, IMPDH1, NT5C2cytosolOne of 5 routes
L-methionineReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
Catalysed by ADSS2, ADSS1, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
L-tryptophanReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
Catalysed by ADSS2, ADSS1, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
beta-alanineReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
Catalysed by ADSS2, ADSS1, GAD2cytosolOne of 2 routes
L-alanineReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. oxaloacetate + L-alanine = L-aspartate + pyruvate
Catalysed by ADSS2, ADSS1, AGXT2cytosol
L-asparagineReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. L-aspartate:L-glutamine amido-ligase (AMP-forming)
Catalysed by ADSS2, ADSS1, ASNScytosolOne of 2 routes
N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)
Catalysed by ADSS2, ADSS1, AGAcytosol
L-phenylalanineReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
Catalysed by ADSS2, ADSS1, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
(2R)-3-phosphoglycerateReach from here →
1. inosine 5'-monophosphate phosphohydrolase
2. inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine
3. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
Catalysed by ACP3, NT5E, NT5C2, NT5C and 6 morecytosol
L-tyrosineReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
Catalysed by ADSS2, ADSS1, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
Catalysed by ADSS2, ADSS1, AGXT2cytosol
(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
1. IMP 1,2-hydrolase (decyclizing)
2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
Catalysed by ATIC, ADSLcytosolOne of 6 routes
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamideReach from here →
1. IMP 1,2-hydrolase (decyclizing)
2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
3. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate
Catalysed by ATICcytosolOne of 2 routes
3-sulfino-L-alanineReach from here →
1. IMP:L-aspartate ligase (GDP-forming)
2. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
Catalysed by ADSS2, ADSS1, SLC25A12, SLC25A13cytosol, mitochondrial matrixOne of 4 routes
dIMPReach from here →
1. IMP:NAD+ oxidoreductase
2. IMP + NAD(+) + H2O = XMP + NADH + H(+)
3. dIMP + inosine = 2'-deoxyinosine + IMP
Catalysed by IMPDH2, IMPDH1, NT5C2cytosolOne of 2 routes
alpha-D-ribose 1,5-bisphosphateReach from here →
1. inosine 5'-monophosphate phosphohydrolase
2. inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine
3. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
Catalysed by ACP3, NT5E, NT5C2, NT5C and 6 morecytosol
3',3'-cGAMPReach from here →
1. IMP 1,2-hydrolase (decyclizing)
2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
3. 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
Catalysed by ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membrane
D-ribose 5-phosphateReach from here →
1. inosine 5'-monophosphate phosphohydrolase
2. inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine
3. alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
Catalysed by ACP3, NT5E, NT5C2, NT5C and 6 morecytosol