CHEBI:16284

Three steps

• palmitoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 3 morecytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by HK1, HK2, HKDC1, GNPNAT1cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 3 morecytosolOne of 43 routes

• (S)-malateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosolOne of 2 routes

• L-leucineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15650Reach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 32 morecytosolOne of 2 routes

• 2'-deoxycytidineReach from here →
  1. ATP:dADP phosphotransferase
  2. cytidine/uridine monophosphate kinase (dADP)
  3. 2'-deoxycytidine 5'-monophosphate phosphohydrolase

  Catalysed by NME4, NME6, NME1, NME2 and 11 morecytosolOne of 8 routes

• CHEBI:15727Reach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 1 morecytosol

• CHEBI:15746Reach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 2 morecytosolOne of 2 routes

• beta-D-glucoseReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. D-Glucose-6-phosphate phosphohydrolase
  3. D-glucose 1-epimerase

  Catalysed by HK1, HK2, HK3, HKDC1 and 4 morecytosol, endoplasmic reticulum

• CHEBI:15971Reach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• dihydroxyacetoneReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
  3. beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate

  Catalysed by HK1, HK2, HKDC1, GNPDA1 and 2 morecytosol

• CHEBI:16108Reach from here →
  1. dATP:D-fructose 6-phosphotransferase
  2. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  3. D-glyceraldehyde-3-phosphate aldose-ketose-isomerase

  Catalysed by HK1, HK2, HK3, HKDC1 and 2 morecytosol

• CHEBI:16132Reach from here →
  1. dATP:D-fructose 6-phosphotransferase
  2. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  3. deoxyribose-phosphate aldolase

  Catalysed by HK1, HK2, HK3, HKDC1 and 2 morecytosol

• D-glucono-1,5-lactoneReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. D-Glucose-6-phosphate phosphohydrolase
  3. D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+)

  Catalysed by HK1, HK2, HK3, HKDC1 and 4 morecytosol, endoplasmic reticulumOne of 2 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol, mitochondrial matrix

• 11-cis-retinolReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 5 morecytosol

• L-valineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• oxaloacetateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol, mitochondrial matrixOne of 4 routes

• L-arginineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. mitothioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrix

• (S)-lactateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by NME4, NME6, NME1, NME2 and 8 morecytosol

• 2-oxobutanoateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• 2-oxoglutaramateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosolOne of 2 routes

• sedoheptuloseReach from here →
  1. dATP:D-fructose 6-phosphotransferase
  2. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  3. ATP:sedoheptulose 7-phosphate

  Catalysed by HK1, HK2, HK3, HKDC1 and 2 morecytosolOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• CHEBI:16857Reach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by NME4, NME6, NME1, NME2 and 9 morecytosol, extracellular spaceOne of 2 routes

• D-xyluloseReach from here →
  1. dATP:D-fructose 6-phosphotransferase
  2. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
  3. ATP:D-xylulose 5-phosphotransferase

  Catalysed by HK1, HK2, HK3, HKDC1 and 4 morecytosol

• methylglyoxalReach from here →
  1. dATP:D-fructose 6-phosphotransferase
  2. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  3. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)

  Catalysed by HK1, HK2, HK3, HKDC1 and 1 morecytosol

• 2'-deoxyguanosineReach from here →
  1. ATP:dADP phosphotransferase
  2. dADP to dATP conversion
  3. 2'-deoxyguanosine 5'-monophosphate phosphohydrolase

  Catalysed by NME4, NME6, NME1, NME2 and 10 morecytosol, mitochondrial matrixOne of 5 routes

• 3-hydroxypyruvateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• L-isoleucineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:17203Reach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• myo-inositolReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. 1D-myo-inositol-3-phosphate lyase (isomerizing)
  3. 1D-myo-inositol 3-phosphate phosphohydrolase

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosolOne of 2 routes

• anilineReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 2 morecytosol

• aceneuramateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• CHEBI:17312Reach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by HK1, HK2, HKDC1, GNPNAT1cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by NME4, NME6, NME1, NME2 and 5 morecytosol

• sulfiteReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. sulfotransferase (thioredoxin)

  Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 3 morecytosol, mitochondrial matrix

• lactoseReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. D-Glucose-6-phosphate phosphohydrolase
  3. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, endoplasmic reticulum

• CHEBI:17797Reach from here →
  1. dATP:D-fructose 6-phosphotransferase
  2. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  3. transketolase (D-xylulose-5-phosphate)

  Catalysed by HK1, HK2, HK3, HKDC1 and 4 morecytosolOne of 2 routes

• CHEBI:17808Reach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. D-Glucose-6-phosphate phosphohydrolase
  3. ITP:D-glucose 6-phosphotransferase

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol, endoplasmic reticulum

• CHEBI:17895Reach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• D-glucitolReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. D-Glucose-6-phosphate phosphohydrolase
  3. Aldehyde Reductase

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol, endoplasmic reticulumOne of 3 routes

• CHEBI:17927Reach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by HK1, HK2, HKDC1, GNPNAT1cytosol

• CHEBI:18019Reach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• L-glutamineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes