phosphatidylethanolamine

Three steps

• octadecanalReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• anilineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 5 moreendoplasmic reticulum, cytosol

• CHEBI:17312Reach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 3 moreendoplasmic reticulum, cytosolOne of 2 routes

• all-trans-retinolReach from here →
  1. Phosphatidylethanolamine N-Methyltransferase
  2. Lecithin Retinol Acyltransferase
  3. carboxylesterase (retinyl-ester)

  Catalysed by PEMT, LRAT, CES2, RBP4 and 18 moremitochondrial matrix, cytosolOne of 2 routes

• AH2Reach from here →
  1. Phosphatidylethanolamine N-Methyltransferase
  2. phosphatidylserine synthase (PC-LD pool)
  3. choline + A = betaine aldehyde + AH2

  Catalysed by PEMT, PTDSS1, CHDHmitochondrial matrix, cytosol

• L-cysteineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 4 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• hexadecanalReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular spaceOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• glycerolReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

  Catalysed by PIGF, PIGG, LIPF, LIPC and 13 moreendoplasmic reticulum, extracellular spaceOne of 2 routes

• CHEBI:17927Reach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 3 moreendoplasmic reticulum, cytosol

• a diacylglycerolReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 22 moreendoplasmic reticulum, cytosolOne of 2 routes

• CHEBI:18132Reach from here →
  1. Phosphatidylethanolamine N-Methyltransferase
  2. phosphatidylserine synthase (PC-LD pool)
  3. ATP:choline phosphotransferase

  Catalysed by PEMT, PTDSS1, CHKA, CHKBmitochondrial matrix, cytosolOne of 5 routes

• D-glucosyl-N-acylsphingosineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. UDP-glucose:N-acylsphingosine D-glucosyltransferase

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 1 moreendoplasmic reticulum, cytosolOne of 2 routes

• a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 1 moreendoplasmic reticulumOne of 2 routes

• a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 2 moreendoplasmic reticulumOne of 2 routes

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 1 moreendoplasmic reticulumOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 morecytosol, extracellular space

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 11 moreendoplasmic reticulum, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 11 moreendoplasmic reticulum, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 9 moreendoplasmic reticulum, cytosolOne of 6 routes

• dodecanalReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 2 H+[r] + lauric acid[r] + NADH[r] = H2O[r] + NAD+[r] + dodecanal[r]

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space, endoplasmic reticulumOne of 3 routes

• CHEBI:28701Reach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, peroxisomeOne of 7 routes

• chlorine(.)Reach from here →
  1. Phosphatidylethanolamine N-Methyltransferase
  2. phosphatidylserine synthase (PC-LD pool)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by PEMT, PTDSS1, SLC5A7mitochondrial matrix, cytosol, extracellular space

• phosphocholineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 1 moreendoplasmic reticulumOne of 4 routes

• acetateReach from here →
  1. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
  2. ethanolamine ammonia-lyase (acetaldehyde-forming)
  3. Acetaldehyde:NAD+ oxidoreductase

  Catalysed by PTDSS2, ALDH3A1, ALDH3B1, ALDH1A3 and 1 morecytosolOne of 4 routes

• an acylcholineReach from here →
  1. Phosphatidylethanolamine N-Methyltransferase
  2. phosphatidylserine synthase (PC-LD pool)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by PEMT, PTDSS1, BCHEmitochondrial matrix, cytosol

• a fatty aldehydeReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
  3. a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)

  Catalysed by PIGF, PIGG, DAGLB, ABHD11 and 2 moreendoplasmic reticulum

• a sterol esterReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 1 moreendoplasmic reticulum

• 12-hydroxydodecanoateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. alkane 1-monooxygenase (lauric acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular spaceOne of 2 routes

• cholesteryl hexadecanoateReach from here →
  1. Phosphatidylethanolamine N-Methyltransferase
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by PEMT, LCATmitochondrial matrix, cytosol, lysosomeOne of 4 routes

• cholesteryl (9Z,12Z)-octadecadienoateReach from here →
  1. Phosphatidylethanolamine N-Methyltransferase
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by PEMT, LCATmitochondrial matrix, cytosol, lysosomeOne of 4 routes

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. Phosphatidylethanolamine N-Methyltransferase
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by PEMT, LCATmitochondrial matrix, cytosol, lysosomeOne of 4 routes

• a 1,3-diacylglycerolReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 5 moreendoplasmic reticulum, cytosolOne of 5 routes

• a 1,2-diacylglycerolReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 7 moreendoplasmic reticulum, cytosolOne of 6 routes

• taurineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 4 moreendoplasmic reticulum, cytosolOne of 2 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol, extracellular space

• 16-hydroxyhexadecanoateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular space, endoplasmic reticulumOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 1 moreendoplasmic reticulumOne of 2 routes

• glycineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 4 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 3 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 4 moreendoplasmic reticulum, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 3 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes