ferricytochrome c

Three steps

• L-methionine (S)-S-oxideReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by LDHD, TYW1B, TYW1, MSRAmitochondrial matrix, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by LDHD, TYW1B, TYW1, MSRB3 and 2 moremitochondrial matrix, cytosol

• S-sulfanylglutathioneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)

  Catalysed by SUOX, SLC25A14, SLC25A30, ETHE1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6, SLC6A12mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• (2S)-2-phospholactateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by LDHD, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, cytosolOne of 2 routes

• L-prolineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by LDHD, AGXT2, SLC1A4mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by LDHD, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• N-benzoylglycineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by SUOX, SLC25A14, SLC25A30, SLC25A12 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-cysteinylglycineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by LDHD, AGXT2, GGTLC3, GGT1 and 4 moremitochondrial matrix, cytosolOne of 2 routes

• dTMPReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate kinase (dTDP)
  3. DTDP Diphosphohydrolase

  Catalysed by LDHD, PKM, PKLR, ENTPD3 and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 5 routes

• ubiquinol-10Reach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by SUOX, SLC25A14, SLC25A30, SQORmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• Mo-molybdopterinReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by LDHD, AGXT2, MOCOSmitochondrial matrix, cytosol

• (2S)-2-aminobutanoateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by LDHD, AGXT2mitochondrial matrix, cytosolOne of 6 routes

• 2-iminobutanoateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by LDHD, AGXT2, RIDAmitochondrial matrix, cytosol

• 2-aminoprop-2-enoateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. D-serine = pyruvate + NH4(+)
  3. D-serine = 2-aminoprop-2-enoate + H2O

  Catalysed by LDHD, SRRmitochondrial matrix, cytosol

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SUOX, STS, CYP3A7mitochondrial matrix, cytosol

• thromboxane B2Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

  Catalysed by LDHD, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 13-oxo-(9Z,11E)-octadecadienoateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O

  Catalysed by CYP1A1, CYP1A2, CYP1B1, CYP2S1 and 1 morecytosol

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  3. glutathione peroxidase (13(S)-HPODE)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 2 routes

• thiamine(1+) diphosphateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  3. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

  Catalysed by LDHD, PDHA1, PDHB, PDHA2 and 1 moremitochondrial matrix, cytosol