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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P33260

CYP2C18

Protein·UNIPROT:P33260Cytochrome P450 2C18

Open in the graph

A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)..

Function from UniProtKB (P33260), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

56 statements

56 statements · 7 reference databases · Subject: CYP2C18 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

CYP2C18 is expressed in ileal mucosaAnatomyBgee ENSG00000108242Inferred only
CYP2C18 is expressed in jejunal mucosaAnatomyBgee ENSG00000108242Inferred only
CYP2C18 is expressed in pancreatic ductal cellCell typeBgee ENSG00000108242Inferred only
CYP2C18 is expressed in right lobe of liverAnatomyBgee ENSG00000108242Inferred only
A2M interacts with CYP2C18ProteinHetionet hetionet:interacts:1562-2Inferred only
APOE interacts with CYP2C18ProteinHetionet hetionet:interacts:1562-348Inferred only
CYP2C18 interacts with ECSITProteinHetionet hetionet:interacts:1562-51295Inferred only
CYP2C18 interacts with SDC2ProteinHetionet hetionet:interacts:1562-6383Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00938Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00935Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00936Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00937Inferred only

Show the remaining 44

(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00939Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR03788Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00956Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00955Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00954Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00951Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00950Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00948Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00947Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00946Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00944Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00943Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00942Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00940Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00931Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00932Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00933Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2C18CompoundHuman-GEM MAR00934Inferred only
15(S)-HPETE is metabolised by CYP2C18CompoundHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2C18CompoundHuman-GEM MAR00993Inferred only
17beta-estradiol is metabolised by CYP2C18CompoundHuman-GEM MAR02042Inferred only
aflatoxin B1 is metabolised by CYP2C18CompoundHuman-GEM MAR07017Inferred only
all-trans-retinoate is metabolised by CYP2C18CompoundRhea RHEA:51984Inferred only
all-trans-retinoic acid is metabolised by CYP2C18CompoundHuman-GEM MAR06658Inferred only
all-trans-retinoic acid is metabolised by CYP2C18CompoundHuman-GEM MAR06657Inferred only
an alcohol is metabolised by CYP2C18CompoundRhea RHEA:17149Inferred only
an organic molecule is metabolised by CYP2C18CompoundRhea RHEA:17149Inferred only
benzo[a]pyrene is metabolised by CYP2C18CompoundHuman-GEM MAR06994Inferred only
benzo[a]pyrene is metabolised by CYP2C18CompoundHuman-GEM MAR06993Inferred only
benzo[a]pyrene is metabolised by CYP2C18CompoundHuman-GEM MAR06992Inferred only
benzo[a]pyrene is metabolised by CYP2C18CompoundHuman-GEM MAR04019Inferred only
estrone is metabolised by CYP2C18CompoundHuman-GEM MAR02054Inferred only
trichloroethene is metabolised by CYP2C18CompoundHuman-GEM MAR07030Inferred only
trichloroethene is metabolised by CYP2C18CompoundHuman-GEM MAR07033Inferred only
CYP2C18 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
CYP2C18 participates in Cytochrome P450 - arranged by substrate typePathwayReactome R-HSA-211897Inferred only
CYP2C18 participates in Diclofenac metabolic pathwayPathwayWikiPathways WP2491Inferred only
CYP2C18 participates in Eicosanoid metabolism via cytochrome P450 monooxygenases pathwayPathwayWikiPathways WP4720Inferred only
CYP2C18 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CYP2C18 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
CYP2C18 participates in Oxidation by cytochrome P450PathwayWikiPathways WP43Inferred only
CYP2C18 participates in Phase I - Functionalization of compoundsPathwayReactome R-HSA-211945Inferred only
CYP2C18 participates in XenobioticsPathwayReactome R-HSA-211981Inferred only
CYP2C18 requires the cofactor hemeCompoundUniProt P33260Inferred only

Reactions

64 reactions

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or

Other names

2 names

Resolves to: CYP2C18

Also called: CYPIIC18Cytochrome P450-6b/29c

← Every protein Find it in the graph →

and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00931CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01213c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 13 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00932CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01239c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00933CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 15 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1, 1.14.15.3cytosol

Human-GEM MAR00934CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00297c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00935CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00936CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00937CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00938CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00426c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00939CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00430c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00940CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00942CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+FADH2+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+FAD+water

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00943CC BY 4.0Reference data

Show the remaining 52