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Proteins/UNIPROT:Q7Z449

CYP2U1

Protein·UNIPROT:Q7Z449Cytochrome P450 2U11 compound

Open in the graph

A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin..

Function from UniProtKB (Q7Z449), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · metabolized by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

linoleic acidCompoundCHEBI:17351Inferred only60 paths15 endpoints

What the reference databases state

GenCC submitters' classifications

2 rows

hereditary spastic paraplegia has a germline basis in CYP2U1DiseaseGenCC HGNC:20582|MONDO:0019064Inferred only
hereditary spastic paraplegia 56 has a germline basis in CYP2U1DiseaseGenCC HGNC:20582|MONDO:0014015Inferred only

Statements

51 statements

51 statements · 7 reference databases · Subject: CYP2U1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

CYP2U1 covaries with LGALS7; LGALS7BProteinHetionet hetionet:covaries:113612-653499Inferred only
CYP2U1 covaries with NMUR1ProteinHetionet hetionet:covaries:10316-113612Inferred only
CYP2U1 is expressed in thymusAnatomyBgee ENSG00000155016Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00955Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00931Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00932Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00933Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00934Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00935Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00936Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00937Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00938Inferred only

Show the remaining 39

(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00939Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00940Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00942Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00943Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00944Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00946Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00947Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00948Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00950Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00951Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00954Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundHuman-GEM MAR00956Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundRhea RHEA:39755Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2U1CompoundRhea RHEA:39759Inferred only
15(S)-HPETE is metabolised by CYP2U1CompoundHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2U1CompoundHuman-GEM MAR00991Inferred only
17beta-estradiol is metabolised by CYP2U1CompoundHuman-GEM MAR02043Inferred only
all-trans-retinoic acid is metabolised by CYP2U1CompoundHuman-GEM MAR06658Inferred only
estrone is metabolised by CYP2U1CompoundHuman-GEM MAR02053Inferred only
linoleic acid is metabolised by CYP2U1CompoundHuman-GEM MAR02457Inferred only
linoleic acid is metabolised by CYP2U1CompoundHuman-GEM MAR02458Inferred only
linoleic acid is metabolised by CYP2U1CompoundHuman-GEM MAR02456Inferred only
linoleic acid is metabolised by CYP2U1CompoundHuman-GEM MAR02455Inferred only
CYP2U1 participates in Arachidonate metabolismPathwayReactome R-HSA-2142753Inferred only
CYP2U1 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
CYP2U1 participates in Cytochrome P450 - arranged by substrate typePathwayReactome R-HSA-211897Inferred only
CYP2U1 participates in Defective CYP2U1 causes SPG56PathwayReactome R-HSA-5579011Inferred only
CYP2U1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
CYP2U1 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
CYP2U1 participates in Fatty acid metabolismPathwayReactome R-HSA-8978868Inferred only
CYP2U1 participates in Metabolic disorders of biological oxidation enzymesPathwayReactome R-HSA-5579029Inferred only
CYP2U1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CYP2U1 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
CYP2U1 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
CYP2U1 participates in Miscellaneous substratesPathwayReactome R-HSA-211958Inferred only
CYP2U1 participates in Oxidation by cytochrome P450PathwayWikiPathways WP43Inferred only
CYP2U1 participates in Phase I - Functionalization of compoundsPathwayReactome R-HSA-211945Inferred only
CYP2U1 participates in Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)PathwayReactome R-HSA-2142816Inferred only
CYP2U1 requires the cofactor hemeCompoundUniProt Q7Z449Inferred only

Reactions

48 reactions

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or

Other names

1 name

Resolves to: CYP2U1

Also called: Long-chain fatty acid omega-monooxygenase

← Every protein Find it in the graph →

and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00931CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01213c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 13 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00932CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01239c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00933CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 15 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1, 1.14.15.3cytosol

Human-GEM MAR00934CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00297c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00935CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00936CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00937CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00938CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00426c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00939CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00430c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00940CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00942CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+FADH2+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+FAD+water

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00943CC BY 4.0Reference data

Show the remaining 36