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Proteins/UNIPROT:Q9HB55

CYP3A43

Protein·UNIPROT:Q9HB55Cytochrome P450 3A431 compound

Open in the graph

Exhibits low testosterone 6-beta-hydroxylase activity in vitro. The physiological substrate of this enzyme is unknown..

Function from UniProtKB (Q9HB55), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · metabolized by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

linoleic acidCompoundCHEBI:17351Inferred only36 paths9 endpoints

What the reference databases state

Statements

55 statements

55 statements · 6 reference databases · Subject: CYP3A43 · Sources: Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

CYP3A43 is expressed in liverAnatomyHuman Protein Atlas ENSG00000021461Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00955Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00942Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00943Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00944Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00946Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00947Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00948Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00950Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00951Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00954Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00956Inferred only

Show the remaining 43

(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR03788Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00931Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00932Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00933Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00934Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00935Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00936Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00937Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00938Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00939Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP3A43CompoundHuman-GEM MAR00940Inferred only
15(S)-HPETE is metabolised by CYP3A43CompoundHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP3A43CompoundHuman-GEM MAR00993Inferred only
17beta-estradiol is metabolised by CYP3A43CompoundHuman-GEM MAR02042Inferred only
17beta-estradiol is metabolised by CYP3A43CompoundHuman-GEM MAR02043Inferred only
aflatoxin B1 is metabolised by CYP3A43CompoundHuman-GEM MAR07017Inferred only
aflatoxin B1 is metabolised by CYP3A43CompoundHuman-GEM MAR07021Inferred only
all-trans-retinoic acid is metabolised by CYP3A43CompoundHuman-GEM MAR06658Inferred only
all-trans-retinoic acid is metabolised by CYP3A43CompoundHuman-GEM MAR06657Inferred only
an alcohol is metabolised by CYP3A43CompoundRhea RHEA:17149Inferred only
an organic molecule is metabolised by CYP3A43CompoundRhea RHEA:17149Inferred only
benzo[a]pyrene is metabolised by CYP3A43CompoundHuman-GEM MAR06994Inferred only
benzo[a]pyrene is metabolised by CYP3A43CompoundHuman-GEM MAR06993Inferred only
benzo[a]pyrene is metabolised by CYP3A43CompoundHuman-GEM MAR04019Inferred only
benzo[a]pyrene is metabolised by CYP3A43CompoundHuman-GEM MAR06992Inferred only
estrone is metabolised by CYP3A43CompoundHuman-GEM MAR02053Inferred only
estrone is metabolised by CYP3A43CompoundHuman-GEM MAR02054Inferred only
linoleic acid is metabolised by CYP3A43CompoundHuman-GEM MAR02458Inferred only
linoleic acid is metabolised by CYP3A43CompoundHuman-GEM MAR02455Inferred only
linoleic acid is metabolised by CYP3A43CompoundHuman-GEM MAR02456Inferred only
linoleic acid is metabolised by CYP3A43CompoundHuman-GEM MAR02457Inferred only
trichloroethene is metabolised by CYP3A43CompoundHuman-GEM MAR07033Inferred only
trichloroethene is metabolised by CYP3A43CompoundHuman-GEM MAR07030Inferred only
CYP3A43 participates in Aripiprazole metabolic pathwayPathwayWikiPathways WP2640Inferred only
CYP3A43 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
CYP3A43 participates in Cytochrome P450 - arranged by substrate typePathwayReactome R-HSA-211897Inferred only
CYP3A43 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CYP3A43 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
CYP3A43 participates in Miscellaneous substratesPathwayReactome R-HSA-211958Inferred only
CYP3A43 participates in Oxidation by cytochrome P450PathwayWikiPathways WP43Inferred only
CYP3A43 participates in Phase I - Functionalization of compoundsPathwayReactome R-HSA-211945Inferred only
CYP3A43 participates in XenobioticsPathwayReactome R-HSA-211981Inferred only
CYP3A43 requires the cofactor hemeCompoundUniProt Q9HB55Inferred only

Reactions

78 reactions

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or

Other names

1 name

Resolves to: CYP3A43

Also called: Cytochrome P450 3A43

← Every protein Find it in the graph →

and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00931CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01213c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 13 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00932CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01239c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00933CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 15 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1, 1.14.15.3cytosol

Human-GEM MAR00934CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00297c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00935CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00936CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00937CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00938CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00426c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00939CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00430c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00940CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00942CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+FADH2+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+FAD+water

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00943CC BY 4.0Reference data

Show the remaining 66