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Proteins/UNIPROT:P20853

CYP2A7

Protein·UNIPROT:P20853Cytochrome P450 2A71 compound

Open in the graph

Xenobiotic-metabolizing enzyme that can catalyze the hydroxylation of species-specific aromatic amine substrates. Catalyzes the hydroxylation of diclofenac to a hydroxydiclofenac metabolite in vitro, suggesting a potential role in drug metabolism. Does not metabolize nicotine, coumarin, or 7-ethoxycoumarin..

Function from UniProtKB (P20853), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · metabolized by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

linoleic acidCompoundCHEBI:17351Inferred only36 paths9 endpoints

What the reference databases state

Statements

49 statements

49 statements · 6 reference databases · Subject: CYP2A7 · Sources: Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

CYP2A7 is expressed in liverAnatomyHuman Protein Atlas ENSG00000198077Inferred only
CYP2A7 is expressed in testisAnatomyHuman Protein Atlas ENSG00000198077Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00948Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00942Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00943Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00944Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00946Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00947Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00950Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR03788Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00956Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00955Inferred only

Show the remaining 37

(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00954Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00951Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00931Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00932Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00933Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00934Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00935Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00936Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00937Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00938Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00939Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A7CompoundHuman-GEM MAR00940Inferred only
15(S)-HPETE is metabolised by CYP2A7CompoundHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2A7CompoundHuman-GEM MAR00993Inferred only
17beta-estradiol is metabolised by CYP2A7CompoundHuman-GEM MAR02043Inferred only
17beta-estradiol is metabolised by CYP2A7CompoundHuman-GEM MAR02042Inferred only
all-trans-retinoic acid is metabolised by CYP2A7CompoundHuman-GEM MAR06658Inferred only
all-trans-retinoic acid is metabolised by CYP2A7CompoundHuman-GEM MAR06657Inferred only
an alcohol is metabolised by CYP2A7CompoundRhea RHEA:17149Inferred only
an organic molecule is metabolised by CYP2A7CompoundRhea RHEA:17149Inferred only
benzo[a]pyrene is metabolised by CYP2A7CompoundHuman-GEM MAR04019Inferred only
estrone is metabolised by CYP2A7CompoundHuman-GEM MAR02054Inferred only
estrone is metabolised by CYP2A7CompoundHuman-GEM MAR02053Inferred only
linoleic acid is metabolised by CYP2A7CompoundHuman-GEM MAR02457Inferred only
linoleic acid is metabolised by CYP2A7CompoundHuman-GEM MAR02458Inferred only
linoleic acid is metabolised by CYP2A7CompoundHuman-GEM MAR02455Inferred only
linoleic acid is metabolised by CYP2A7CompoundHuman-GEM MAR02456Inferred only
CYP2A7 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
CYP2A7 participates in CYP2E1 reactionsPathwayReactome R-HSA-211999Inferred only
CYP2A7 participates in Cytochrome P450 - arranged by substrate typePathwayReactome R-HSA-211897Inferred only
CYP2A7 participates in Fatty acidsPathwayReactome R-HSA-211935Inferred only
CYP2A7 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CYP2A7 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
CYP2A7 participates in Oxidation by cytochrome P450PathwayWikiPathways WP43Inferred only
CYP2A7 participates in Phase I - Functionalization of compoundsPathwayReactome R-HSA-211945Inferred only
CYP2A7 participates in XenobioticsPathwayReactome R-HSA-211981Inferred only
CYP2A7 requires the cofactor hemeCompoundUniProt P20853Inferred only

Reactions

56 reactions

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or

Other names

3 names

Resolves to: CYP2A7

Also called: CYP2A4CYPIIA7Cytochrome P450 IIA4

← Every protein Find it in the graph →

and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00931CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01213c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 13 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00932CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01239c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00933CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 15 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1, 1.14.15.3cytosol

Human-GEM MAR00934CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00297c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00935CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00936CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00937CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00938CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00426c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00939CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00430c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00940CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00942CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+FADH2+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+FAD+water

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00943CC BY 4.0Reference data

Show the remaining 44