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Proteins/UNIPROT:P11509

CYP2A6

Protein·UNIPROT:P115091 compound

Open in the graph

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide, ifosphamide and tegafur. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity..

Function from UniProtKB (P11509), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · metabolized by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

linoleic acidCompoundCHEBI:17351Inferred only78 paths21 endpoints

What the reference databases state

Statements

59 statements

59 statements · 5 reference databases · Subject: CYP2A6 · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways

Search this listOrder

CYB5A interacts with CYP2A6ProteinHetionet hetionet:interacts:1528-1548Inferred only
CYP2A6 interacts with PORProteinHetionet hetionet:interacts:1548-5447Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00938Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00940Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00931Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00932Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00933Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00934Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00935Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00936Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00937Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00939Inferred only

Show the remaining 47

(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR03788Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00956Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00955Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00954Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00951Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00950Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00948Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00947Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00946Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00944Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00943Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is metabolised by CYP2A6CompoundHuman-GEM MAR00942Inferred only
15(S)-HPETE is metabolised by CYP2A6CompoundHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2A6CompoundHuman-GEM MAR00991Inferred only
17beta-estradiol is metabolised by CYP2A6CompoundHuman-GEM MAR02042Inferred only
17beta-estradiol is metabolised by CYP2A6CompoundHuman-GEM MAR02043Inferred only
all-trans-retinoic acid is metabolised by CYP2A6CompoundHuman-GEM MAR06658Inferred only
all-trans-retinoic acid is metabolised by CYP2A6CompoundHuman-GEM MAR06657Inferred only
benzo[a]pyrene is metabolised by CYP2A6CompoundHuman-GEM MAR04019Inferred only
estrone is metabolised by CYP2A6CompoundHuman-GEM MAR02053Inferred only
estrone is metabolised by CYP2A6CompoundHuman-GEM MAR02054Inferred only
linoleic acid is metabolised by CYP2A6CompoundHuman-GEM MAR02456Inferred only
linoleic acid is metabolised by CYP2A6CompoundHuman-GEM MAR02455Inferred only
linoleic acid is metabolised by CYP2A6CompoundHuman-GEM MAR02457Inferred only
linoleic acid is metabolised by CYP2A6CompoundHuman-GEM MAR02458Inferred only
paracetamol is metabolised by CYP2A6CompoundHuman-GEM MAR12387Inferred only
CYP2A6 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
CYP2A6 participates in Caffeine and theobromine metabolismPathwayWikiPathways WP3633Inferred only
CYP2A6 participates in Constitutive androstane receptor pathwayPathwayWikiPathways WP2875Inferred only
CYP2A6 participates in CYP2E1 reactionsPathwayReactome R-HSA-211999Inferred only
CYP2A6 participates in Cytochrome P450 - arranged by substrate typePathwayReactome R-HSA-211897Inferred only
CYP2A6 participates in Fatty acid omega oxidationPathwayWikiPathways WP206Inferred only
CYP2A6 participates in Fluoropyrimidine activityPathwayWikiPathways WP1601Inferred only
CYP2A6 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CYP2A6 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
CYP2A6 participates in Nicotine metabolism in liver cellsPathwayWikiPathways WP1600Inferred only
CYP2A6 participates in NRF2 pathwayPathwayWikiPathways WP2884Inferred only
CYP2A6 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
CYP2A6 participates in Oxidation by cytochrome P450PathwayWikiPathways WP43Inferred only
CYP2A6 participates in Phase I - Functionalization of compoundsPathwayReactome R-HSA-211945Inferred only
CYP2A6 participates in Pregnane X receptor pathwayPathwayWikiPathways WP2876Inferred only
CYP2A6 participates in Quercetin and Nf kB AP 1 induced apoptosisPathwayWikiPathways WP2435Inferred only
CYP2A6 participates in Retinol metabolismPathwayWikiPathways WP5188Inferred only
CYP2A6 participates in Tamoxifen metabolismPathwayWikiPathways WP691Inferred only
CYP2A6 participates in Valproic acid pathwayPathwayWikiPathways WP3871Inferred only
CYP2A6 participates in XenobioticsPathwayReactome R-HSA-211981Inferred only
CYP2A6 requires the cofactor hemeCompoundUniProt P11509Inferred only

Reactions

57 reactions

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or

Other names

6 names

Resolves to: CYP2A6

Also called: 1,4-cineole 2-exo-monooxygenaseCoumarin 7-hydroxylaseCYP2A3CYPIIA6Cytochrome P450 IIA3Cytochrome P450(I)

← Every protein Find it in the graph →

and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00931CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01213c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 13 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00932CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM01239c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00933CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 15 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1, 1.14.15.3cytosol

Human-GEM MAR00934CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00297c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00935CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00936CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00937CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00938CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00426c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00939CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygenMAM00430c+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00940CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+proton+NADPH(4-)+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+water+NADP(3-)

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00942CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+FADH2+dioxygen5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+FAD+water

Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives

Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol

Human-GEM MAR00943CC BY 4.0Reference data

Show the remaining 45