Proteins/UNIPROT:Q5R3K3

CALHM6

ProteinUNIPROT:Q5R3K3

Pore-forming subunit of an ATP-permeable channel (By similarity). In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (By similarity). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels..

Function from UniProtKB (Q5R3K3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: CALHM6 · Sources: gene ontology, Hetionet, Rhea

Order

CALHM6 covaries with CTPS1ProteinHetionet hetionet:covaries:1503-441168Inferred only
CALHM6 covaries with ING4ProteinHetionet hetionet:covaries:441168-51147Inferred only
CALHM6 covaries with NDUFAB1ProteinHetionet hetionet:covaries:441168-4706Inferred only
CALHM6 covaries with NHLH2ProteinHetionet hetionet:covaries:441168-4808Inferred only
CALHM6 covaries with SLC3A1ProteinHetionet hetionet:covaries:441168-6519Inferred only
CALHM6 covaries with SVBPProteinHetionet hetionet:covaries:374969-441168Inferred only
CALHM6 regulates regulation of natural killer cell cytokine productionBiological processgene ontology Q5R3K3|GO:0002727Inferred only
ATP(4-) is transported by CALHM6CompoundRhea RHEA:75687Inferred only

Reactions

1 reaction

ATP(4-)ATP(4-)
Transported by VDAC1 or CALHM6 or CALHM3 or CALHM1 or PANX3 or PANX2 or PANX1 or SLC17A9 or SLC29A3 or CALHM2 or ANKH
Reaction pageLeft to rightBalanced
Rhea RHEA:75687CC BY 4.0Reference data

Other names

4 names

Resolves to: CALHM6

Also called: C6orf187Calcium homeostasis modulator protein 6FAM26FProtein FAM26F

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