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Reference

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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9HA72

CALHM2

Protein·UNIPROT:Q9HA72

Open in the graph

Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown..

Function from UniProtKB (Q9HA72), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

5 statements

5 statements · 3 reference databases · Subject: CALHM2 · Sources: gene ontology, Hetionet, Rhea

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SAXO2 covaries with CALHM2ProteinHetionet hetionet:covaries:283726-51063Inferred only
CALHM2 regulates positive regulation of apoptotic processBiological processgene ontology Q9HA72|GO:0043065Inferred only
CALHM2 regulates regulation of microglial cell activationBiological processgene ontology Q9HA72|GO:1903978Inferred only
CALHM2 regulates regulation of synaptic plasticityBiological processgene ontology Q9HA72|GO:0048167Inferred only
ATP(4-) is transported by CALHM2CompoundRhea RHEA:75687Inferred only

Reactions

1 reaction

ATP(4-)ATP(4-)
Transported by VDAC1 or CALHM6 or CALHM3 or CALHM1 or PANX3 or PANX2 or PANX1 or SLC17A9 or SLC29A3 or CALHM2 or ANKH
Reaction pageLeft to rightBalanced
Rhea RHEA:75687CC BY 4.0Reference data

Other names

3 names

Resolves to: CALHM2

Also called: Calcium homeostasis modulator protein 2FAM26BProtein FAM26B

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