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Proteins/UNIPROT:P23975
Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system. Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (By similarity). Can also mediate sodium- and chloride-dependent transport of dopamine..
Function from UniProtKB (P23975), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
37 statements
37 statements · 6 reference databases · Subject: SLC6A2 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
2sodium(1+)+(R)-noradrenaline2sodium(1+)+(R)-noradrenaline
Transported by SLC6A2 or SLC6A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06242CC BY 4.0Reference data
6 names
Resolves to: SLC6A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06733CC BY 4.0Reference data
sodium(1+)+(R)-noradrenalinesodium(1+)+(R)-noradrenaline
Transported by SLC6A2 or SLC6A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09615CC BY 4.0Reference data
dopamine+chloride+sodium(1+)dopamine+chloride+sodium(1+)
Transported by SLC6A2 or SLC6A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:70919CC BY 4.0Reference data
(R)-noradrenaline+chloride+sodium(1+)(R)-noradrenaline+chloride+sodium(1+)
Transported by SLC6A2 or SLC6A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:70923CC BY 4.0Reference data
dopamine+chloride+2sodium(1+)dopamine+chloride+2sodium(1+)
Transported by SLC6A2 or SLC6A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:70931CC BY 4.0Reference data