Proteins/UNIPROT:Q86Y56

DNAAF5

ProteinUNIPROT:Q86Y56

Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility..

Function from UniProtKB (Q86Y56), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

primary ciliary dyskinesia has a germline basis in DNAAF5DiseaseGenCC HGNC:26013|MONDO:0016575Inferred only
primary ciliary dyskinesia 18 has a germline basis in DNAAF5DiseaseGenCC HGNC:26013|MONDO:0013940Inferred only

Statements

19 statements

19 statements · 2 reference databases · Subject: DNAAF5 · Sources: Hetionet, WikiPathways

Order

DNAAF5 covaries with AP5Z1ProteinHetionet hetionet:covaries:54919-9907Inferred only
DNAAF5 covaries with GPR146ProteinHetionet hetionet:covaries:115330-54919Inferred only
DNAAF5 covaries with IGF2RProteinHetionet hetionet:covaries:3482-54919Inferred only
DNAAF5 covaries with INTS1ProteinHetionet hetionet:covaries:26173-54919Inferred only
DNAAF5 covaries with MEGF6ProteinHetionet hetionet:covaries:1953-54919Inferred only
DNAAF5 covaries with PLCH2ProteinHetionet hetionet:covaries:54919-9651Inferred only
DNAAF5 covaries with SNAPC4ProteinHetionet hetionet:covaries:54919-6621Inferred only
SUN1 covaries with DNAAF5ProteinHetionet hetionet:covaries:23353-54919Inferred only
FEZ1 interacts with DNAAF5ProteinHetionet hetionet:interacts:54919-9638Inferred only
PPP2R1B interacts with DNAAF5ProteinHetionet hetionet:interacts:54919-5519Inferred only
SUMO2 interacts with DNAAF5ProteinHetionet hetionet:interacts:54919-6613Inferred only
UBC interacts with DNAAF5ProteinHetionet hetionet:interacts:54919-7316Inferred only

Show the remaining 7

ZBTB16 interacts with DNAAF5ProteinHetionet hetionet:interacts:54919-7704Inferred only
DNAAF5 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
HDAC2 decreases the expression of DNAAF5ProteinHetionet hetionet:regulates:3066-54919Inferred only
HMGB1 increases the expression of DNAAF5ProteinHetionet hetionet:regulates:3146-54919Inferred only
KDELR2 decreases the expression of DNAAF5ProteinHetionet hetionet:regulates:11014-54919Inferred only
P4HA1 increases the expression of DNAAF5ProteinHetionet hetionet:regulates:5033-54919Inferred only
RPA3 decreases the expression of DNAAF5ProteinHetionet hetionet:regulates:6119-54919Inferred only

Other names

3 names

Resolves to: DNAAF5

Also called: Dynein axonemal assembly factor 5HEAT repeat-containing protein 2HEATR2

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