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Proteins/UNIPROT:Q9NWX6
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress..
Function from UniProtKB (Q9NWX6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
20 statements
20 statements · 3 reference databases · Subject: THG1L · Sources: Hetionet, Reactome, UniProt
1 reaction
a 5'-end ribonucleotide-tRNA(His)+GTP+ATP(4-)+watera 5'-end phospho-guanosine-ribonucleotide-tRNA(His)+AMP+2diphosphate(3-)+hydron
Catalysed by THG1L
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:54564CC BY 4.0Reference data
6 names
Resolves to: THG1L