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Proteins/UNIPROT:Q9HD20
Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains..
Function from UniProtKB (Q9HD20), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 2 reference databases · Subject: ATP13A1 · Sources: Hetionet, Reactome
1 reaction
[protein]-with a C-terminal TM segment+ATP(4-)+water[protein]-with a C-terminal TM segment+ADP(3-)+hydrogenphosphate+hydron
Transported by ATAD1 or ATP13A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:66168CC BY 4.0Reference data
3 names
Resolves to: ATP13A1