Loading the page.
Proteins/UNIPROT:Q9NYR8
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity)..
Function from UniProtKB (Q9NYR8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
29 statements
29 statements · 5 reference databases · Subject: RDH8 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
9-cis-retinol+NADP(3-)9-cis-retinal+proton+NADPH(4-)
Catalysed by RDH11 or RDH8 or RDH12 or RDH13 or SDR16C5 or RDH14
Reaction pageLeft to rightBalancedEC 1.1.1.105cytosol
Human-GEM MAR01690CC BY 4.0Reference data
4 names
Resolves to: RDH8
Reaction pageLeft to rightBalancedEC 1.1.1.300cytosol
Human-GEM MAR06630CC BY 4.0Reference data
NADP(3-)+all-trans-retinolproton+NADPH(4-)+all-trans-retinal
Catalysed by RDH11 or DHRS9 or RDH8 or RDH10 or RDH12 or DHRS3
Reaction pageLeft to rightBalancedEC 1.1.1.300endoplasmic reticulum
Human-GEM MAR06632CC BY 4.0Reference data
all-trans-retinol+NADP(3-)all-trans-retinal+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or DHRS3 or AKR1B1 or RDH10 or RDH13 or RDH11 or RDH12 or RDH14 or RDH8 or DHRS7
Reaction pageRight to leftBalanced
Rhea RHEA:25033CC BY 4.0Reference data