Pathway
Synthesis of bile acids and bile salts
In a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily. The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol to 7alpha-hydroxycholesterol. Bile salt synthesis can also begin with the synthesis of an oxysterol - 24-hydroxycholesterol or 27-hydroxycholesterol. In the body, the initial steps of these two pathways occur in extrahepatic tissues, generating intermediates that are transported to the liver and converted to bile salts via the 7alpha-hydroxycholesterol pathway. These extrahepatic pathways contribute little to the total synthesis of bile salts, but are thought to play important roles in cholesterol homeostasis.
REACT:R-HSA-192105Reactome
What the reference databases state
Statements
33 statements
33 statements · 1 reference database · Subject: Synthesis of bile acids and bile salts · Sources: Reactome
- ABCB11 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- ABCD3 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- ACOT8 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- ACOX2 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- AKR1C1 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- AKR1C2 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- AKR1C3 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- AKR1C4 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- AKR1D1 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- AMACR participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- BAAT participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- CH25H participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
Show the remaining 21
- CYP27A1 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- CYP39A1 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- CYP46A1 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- CYP7A1 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- CYP7B1 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- CYP8B1 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- HSD17B4 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- HSD3B7 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- NCOA1 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- NCOA2 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- NR1H4 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- OSBP participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- OSBPL1A participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- OSBPL2 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- OSBPL3 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- OSBPL6 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- OSBPL7 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- OSBPL9 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- RXRA participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- SLC27A2 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only
- SLC27A5 participates in Synthesis of bile acids and bile saltsProteinReactome R-HSA-192105Inferred only