3-oxohexacosanoyl-CoA

Three steps

• L,L-cystathionineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 1 moreperoxisome, cytosol, mitochondrial matrix

• (3Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, AGPAT2, GPAT3 and 11 moreperoxisome, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 2 moreperoxisome, cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 2 moreperoxisome, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 6 moreperoxisome, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 12 routes

• a cardiolipinReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by ACAA1, MYO5B, HADHAperoxisome, cytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 2 moreperoxisome, cytosol

• an all-trans-retinyl esterReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by ACAA1, MYO5B, DGAT1, PNPLA4 and 2 moreperoxisome, cytosol

• CHEBI:63544Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 8 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 2 moreperoxisome, cytosol

• a triacyl-sn-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, DGAT1, MOGAT2 and 4 moreperoxisome, cytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACAA1, MYO5B, LCLAT1, LPCAT1 and 1 moreperoxisome, cytosol

• hexacosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• N-docosanoylsphinganineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. docosanoyl-CoA + sphinganine = N-docosanoylsphinganine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 4 moreperoxisome

• N-eicosanoylsphinganineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 4 moreperoxisome

• (2E)-octadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosolOne of 3 routes

• 3-oxodocosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 8 moreperoxisome, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 9 routes

• N-eicosanoyl-sphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 3 moreperoxisome

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 7 routes

• 3-oxotetracosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 8 moreperoxisome, cytosolOne of 3 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 5 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxo-hexacosenoyl-CoA)
  2. (15Z)-tetracosenoyl-CoA hydrolase
  3. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 3 moreperoxisome, cytosol

• (2E)-eicosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. acyl-CoA oxidase (eicosanoyl-CoA)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 2 moreperoxisomeOne of 4 routes

• (2E)-docosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. acyl-CoA oxidase (docosanoyl-CoA)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 2 moreperoxisomeOne of 4 routes

• 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 2 moreperoxisome

• nonadecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosolOne of 3 routes

• a 2,3-diacyl-sn-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, MOGAT1peroxisome, cytosol

• eicosan-1-olReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + 2 NADPH + 2 H(+) = eicosan-1-ol + 2 NADP(+) + CoA

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 3 moreperoxisome

• (R)-2-hydroxytetracosanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. tetracosanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 1 moreperoxisome, cytosol

• 1-O-alkyl-3-acylglycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, AWAT2peroxisome, cytosol

• dodecanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Activation of dodecanedioic acid

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Production of Sebacoylcarnitine

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Production of Suberylcarnitine

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosolOne of 4 routes