3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA

Three steps

• 3-hydroxyisovaleryl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 4 morecytosol

• an all-trans-retinyl esterReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by ACAA1, DGAT1, PNPLA4, AWAT2 and 1 morecytosol

• CHEBI:63544Reach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 8 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, LPCAT4, LPCAT3, MBOAT1 and 1 morecytosol

• a triacyl-sn-glycerolReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by ACAA1, DGAT1, MOGAT2, AWAT2 and 3 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACAA1, LCLAT1, LPCAT1, GPAMcytosol

• hexacosanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 11 routes

• docosanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 10 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 9 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. fatty-acyl-CoA elongation (N-C18:3CoA)
  3. Dihomo-gamma-linolenoyl-CoA hydrolase

  Catalysed by ACAA1, ELOVL4, ELOVL6, ELOVL2 and 6 morecytosol

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 7 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 5 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 6 routes

• nonadecanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 3 routes

• 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Beta Oxidation of Fatty Acid
  3. octanoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, ACADM, ACADS, LPCAT4mitochondrial matrix

• 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Beta Oxidation of Fatty Acid
  3. octanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, ACADM, ACADS, LPCAT1mitochondrial matrix

• a 2,3-diacyl-sn-glycerolReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MOGAT2, MOGAT1cytosol

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Beta Oxidation of Fatty Acid
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by ACAA1, ACADM, ACADS, LCLAT1mitochondrial matrix

• 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Beta Oxidation of Fatty Acid
  3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by ACAA1, ACADM, ACADS, LCLAT1mitochondrial matrix

• 1-O-alkyl-3-acylglycerolReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by ACAA1, MOGAT2, AWAT2cytosol

• dodecanedioyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Activation of dodecanedioic acid

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Production of Sebacoylcarnitine

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Production of Suberylcarnitine

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 6 routes

• (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. fatty-acyl-CoA elongation (N-C18:3CoA)
  3. ELOVL fatty acid elongase (trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA)

  Catalysed by ACAA1, ELOVL4, ELOVL6, ELOVL2 and 2 morecytosol, endoplasmic reticulumOne of 2 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 6 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 4 morecytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. Gamma-linolenoyl-CoA hydrolase
  3. fatty-acid-CoA ligase

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 3 morecytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MOGAT1cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, LPCAT2, LPCAT1cytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, LPCAT4cytosol