N,N-dimethylglycine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

81 compounds within 3 steps: 1 in 1, 2 in 2, 78 in 3

Three steps

chlorine(.)Reach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. transport of chloride and glycine (cytosol to extracellular)
Catalysed by DMGDH, PIPOX, SLC6A9, SLC6A14extracellular space, cytosolOne of 3 routes
glycocholateReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by DMGDH, PIPOX, BAATperoxisomeOne of 3 routes
5-aminolevulinateReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA
Catalysed by DMGDH, PIPOX, ALAS1, ALAS2
glycochenodeoxycholateReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
Catalysed by DMGDH, PIPOX, BAAT
glycochenodeoxycholic acidReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by DMGDH, PIPOX, BAATperoxisomeOne of 3 routes
glyoxylateReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
Catalysed by DMGDH, PIPOX, AADATOne of 11 routes
glycolithocholic acidReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. bile acid-CoA:amino acid N-acyltransferase (glycine)
Catalysed by DMGDH, PIPOX, BAATcytosolOne of 2 routes
L-2-amino-3-oxobutanoic acidReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. Acetyl-CoA:glycine C-acetyltransferase
Catalysed by DMGDH, PIPOX, GCATmitochondrial matrix
L-ornithineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. L-Arginine:glycine amidinotransferase
Catalysed by DMGDH, PIPOX, GATMcytosolOne of 5 routes
S(8)-aminomethyldihydrolipoamideReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)
Catalysed by DMGDH, PIPOX, GLDC, GCSHmitochondrial matrix
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Catalysed by DMGDH, PIPOX, SHMT1, SHMT2
an N-acylglycineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by DMGDH, PIPOX, GLYATL3, GLYAT and 1 more
S-formylglutathioneReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. alcohol dehydrogenase (formaldehyde)
Catalysed by DMGDH, PIPOX, ADH1C, ADH1A and 4 morecytosol
guanidinoacetateReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. L-Arginine:glycine amidinotransferase
Catalysed by DMGDH, PIPOX, GATMcytosolOne of 2 routes
L-methionineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. transport of glycine and methionine (cytosol to extracellular)
Catalysed by DMGDH, PIPOX, SLC7A5extracellular space, cytosolOne of 5 routes
L-tryptophanReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. transport of glycine and tryptophan (cytosol to extracellular)
Catalysed by DMGDH, PIPOX, SLC7A5extracellular space, cytosolOne of 5 routes
glutathioneReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by DMGDH, PIPOX, GSS
L-alanineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. transport of alanine and glycine (cytosol to extracellular)
Catalysed by DMGDH, PIPOX, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 6 routes
leukotriene C4Reach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. leukotriene C4 hydrolysis
Catalysed by DMGDH, PIPOXcytosol
L-asparagineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. transport of asparagine and glycine (cytosol to extracellular)
Catalysed by DMGDH, PIPOXextracellular space, cytosolOne of 4 routes
L-phenylalanineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. transport of glycine and phenylalanine (cytosol to extracellular)
Catalysed by DMGDH, PIPOX, SLC7A5extracellular space, cytosolOne of 7 routes
L-tyrosineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by DMGDH, PIPOX, AADAT
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by DMGDH, PIPOX, AGXT2
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
Catalysed by DMGDH, PIPOX, GLYATL2One of 2 routes
N-benzoylglycineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. Hippurate (Benzoylglycinate) Formation
Catalysed by DMGDH, PIPOXmitochondrial matrixOne of 2 routes
(2S)-2-aminobutanoateReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by DMGDH, PIPOX, AGXT2
glycodeoxycholateReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. Glycodeoxycholate amidohydrolase
Catalysed by DMGDH, PIPOXcytosolOne of 2 routes
N-tetradecanoylglycineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by DMGDH, PIPOX, GLYATL2
N-eicosanoylglycinateReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by DMGDH, PIPOX, BAAT
N-docosanoylglycineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by DMGDH, PIPOX, BAAT
N-hexacosanoylglycineReach from here →
1. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by DMGDH, PIPOX, BAAT