O-octanoyl-(R)-carnitine

Three steps

• 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC25A20, CYP1A1, CYP1A2, CYP2E1 and 23 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• S-butanoyl-4'-phosphopantetheineReach from here →
  1. solute carrier (L-carnitine)
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLC25A20, SLC33A1, ESCO2, OXSM and 3 moremitochondrial matrix, cytosol

• decanoyl-4'-phosphopantetheineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. fatty acyl-CoA synthase (N-C10:0CoA)
  3. decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CROT, NUDT7mitochondrial matrix, cytosol

• 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC25A20, CYP1A1, CYP1A2, CYP2E1 and 23 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A20, CYP1A1mitochondrial matrix, cytosol, endoplasmic reticulum

• prostaglandin G1Reach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1

  Catalysed by SLC25A20, PTGS2mitochondrial matrix, cytosol, endoplasmic reticulum

• 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A20, CYP3A4, CYP2C9mitochondrial matrix, cytosol, endoplasmic reticulum

• (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

  Catalysed by SLC25A20, ALOX15mitochondrial matrix, cytosol, endoplasmic reticulum

• (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

  Catalysed by SLC25A20, ALOX15mitochondrial matrix, cytosol, endoplasmic reticulum

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by SLC25A20, SLCO1B1mitochondrial matrix, cytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by SLC25A20, PM20D1mitochondrial matrix, cytosol, endoplasmic reticulum

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by SLC25A20, PM20D1mitochondrial matrix, cytosol, endoplasmic reticulum

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by SLC25A20, PM20D1mitochondrial matrix, cytosol, endoplasmic reticulum

• 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC25A20, CYP1A1, CYP1A2, CYP2E1 and 23 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC25A20, CYP1A1, CYP1A2, CYP2E1 and 23 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A20, CYP2C9mitochondrial matrix, cytosol, endoplasmic reticulum

• 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC25A20, CYP1A1, CYP1A2, CYP2E1 and 23 moremitochondrial matrix, cytosol, endoplasmic reticulum

• 2-hydroxydecanoyl-CoAReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. fatty acyl-CoA synthase (N-C10:0CoA)
  3. decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2

  Catalysed by CROT, PHYHmitochondrial matrix, cytosol

• N-decanoylglycineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. fatty acyl-CoA synthase (N-C10:0CoA)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by CROT, GLYATL2mitochondrial matrix, cytosol

• N-octanoyl-(2S)-hydroxyglycineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)
  3. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by CROT, GLYATL2, PAMmitochondrial matrix

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by SLC25A20mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by SLC25A20, FAAH, PM20D1mitochondrial matrix, cytosol, endoplasmic reticulum

• (7Z)-octadecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

• CHEBI:15345Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosolOne of 2 routes

• cholineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol, nucleusOne of 2 routes

• CHEBI:15380Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosolOne of 8 routes

• CHEBI:15477Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol

• isovaleryl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 14 routes

• CHEBI:15519Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 18 routes

• oleoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 14 routes

• phenylacetyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

• L-leucineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 12(S)-HPETEReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by SLC25A20, ALOX12mitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• 15(S)-HPETEReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by SLC25A20, ALOX15B, ALOX15mitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• 5(S)-HPETEReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by SLC25A20, ALOX5mitochondrial matrix, cytosol, endoplasmic reticulum

• CHEBI:15650Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 32 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol

• CHEBI:15746Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular space

• sulfateReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14, SLC26A6mitochondrial matrix, cytosol, extracellular space

• 11-cis-retinolReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 5 moremitochondrial matrix, cytosol

• iodideReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14, SLC26A4mitochondrial matrix, cytosol, extracellular space

• L-valineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• oxaloacetateReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol

• L-arginineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes