keto-D-fructose 6-phosphate

Three steps

• sphing-4-enineReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GFPT2, GFPT1, GNPNAT1, ASAH1 and 3 morecytosol, Golgi apparatusOne of 2 routes

• N-acetyl-alpha-D-glucosamine 1-phosphateReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate

  Catalysed by GFPT2, GFPT1, GNPNAT1, PGM3cytosol

• spermidineReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SAT1 and 1 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by GFPT2, GFPT1, GNPNAT1, NAGScytosol, mitochondrial matrix

• L-alanineReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by GFPT2, GFPT1, GNPNAT1cytosol, mitochondrial matrix

• 5-phospho-alpha-D-ribose 1-diphosphateReach from here →
  1. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  2. transketolase (D-xylulose-5-phosphate)
  3. ATP:D-ribose-5-phosphate diphosphotransferase

  Catalysed by TALDO1, TKT, TKTL1, TKTL2 and 3 morecytosol

• L-asparagineReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by GFPT2, GFPT1, GNPNAT1, NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by GFPT2, GFPT1, GNPNAT1, NAGScytosol, mitochondrial matrix

• alpha-D-glucose 6-phosphateReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
  3. alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate

  Catalysed by GFPT2, GFPT1, GNPDA1, GNPDA2 and 1 morecytosol

• (2R)-3-phosphoglycerateReach from here →
  1. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  2. D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
  3. ATP:3-phospho-D-glycerate 1-phosphotransferase

  Catalysed by TALDO1, GAPDHS, GAPDH, PGK1 and 2 morecytosolOne of 9 routes

• aldehydo-D-ribose 5-phosphateReach from here →
  1. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
  2. D-Ribulose-5-phosphate 3-epimerase
  3. aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate

  Catalysed by TKT, TKTL1, TKTL2, RPEL1 and 2 morecytosol

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  2. D-glyceraldehyde-3-phosphate aldose-ketose-isomerase
  3. glyceronephosphate O-acyltransferase (DHAP)

  Catalysed by TALDO1, TPI1, GNPATcytosol, peroxisome

• an acyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GFPT2, GFPT1, GNPNAT1, ASAH1 and 3 morecytosol, Golgi apparatusOne of 2 routes

• alpha-D-glucose 1,6-bisphosphateReach from here →
  1. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  2. D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
  3. 3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase

  Catalysed by TALDO1, GAPDHS, GAPDH, PGM2L1cytosolOne of 3 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by GFPT2, GFPT1, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• D-glucosamine 6-phosphateReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)

  Catalysed by GFPT2, GFPT1, GNPNAT1cytosolOne of 2 routes

• deoxycholoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 1 morecytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, ACSM4 and 5 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by GFPT2, GFPT1, GNPNAT1, CPT1A and 2 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 11 routes

• D-glucose 6-phosphateReach from here →
  1. D-glucose-6-phosphate aldose-ketose-isomerase
  2. D-glucose-6-phosphate:NADP+ 1-oxidoreductase
  3. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)

  Catalysed by GPI, G6PDcytosol, endoplasmic reticulumOne of 4 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by GFPT2, GFPT1, GNPNAT1, CPT1A and 1 morecytosol

• 2-deoxy-D-ribose 5-phosphateReach from here →
  1. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
  2. D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate
  3. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde

  Catalysed by TKT, TKTL1, TKTL2, TALDO1 and 1 morecytosol

• CHEBI:63544Reach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 9 routes

• alpha-D-ribose 1,5-bisphosphateReach from here →
  1. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  2. D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
  3. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)

  Catalysed by TALDO1, GAPDHS, GAPDH, PGM2L1cytosol

• 2-acetamido-2-deoxy-D-glucopyranose 1-phosphateReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. phosphoglucomutase (N-acetylglucosamine-6-phosphate)

  Catalysed by GFPT2, GFPT1, GNPNAT1, PGM3cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by GFPT2, GFPT1, GNPNAT1, CPT1A and 2 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 8 routes

• D-ribulose 1-phosphateReach from here →
  1. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
  2. ATP:D-xylulose 5-phosphotransferase
  3. ketohexokinase (D-xylulose)

  Catalysed by TKT, TKTL1, TKTL2, XYLB and 1 morecytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by GFPT2, GFPT1, GNPNAT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by GFPT2, GFPT1, GNPNAT1, CPT1A and 2 morecytosolOne of 3 routes