palmitoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

829 compounds within 3 steps: 17 in 1, 232 in 2, 580 in 3

Three steps

1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SCD, SCD5, LPGAT1cytosol
1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SCD, SCD5, LPGAT1cytosol
1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SCD, SCD5, LPGAT1cytosol
1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by SCD, SCD5, LCLAT1cytosol
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by SCD, SCD5, LCLAT1cytosol
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SCD, SCD5, LCLAT1, LPGAT1cytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SCD, SCD5, LPCAT4, LCLAT1cytosol
N-dodecanoylsphing-4-enineReach from here →
1. Palmitoyl-CoA hydrolase
2. acyl-CoA:sphingosine N-acyltransferase
3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol, Golgi apparatus
N-tetradecanoylsphing-4-enineReach from here →
1. Palmitoyl-CoA hydrolase
2. acyl-CoA:sphingosine N-acyltransferase
3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, Golgi apparatusOne of 2 routes
N-hexadecanoylsphing-4-enineReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
Catalysed by SCD, SCD5, CERS6, TLCD3B and 2 morecytosolOne of 4 routes
N-eicosanoyl-sphing-4-enineReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosolOne of 2 routes
N-tetracosanoyl-sphing-4-enineReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lignocerate)
3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes
1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
Catalysed by LPCAT3, PLAAT3cytosol
1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SCD, SCD5, PRDX6, LPCAT3 and 1 morecytosol
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by SCD, SCD5, LPGAT1cytosolOne of 2 routes
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 12 morecytosol
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SCD, SCD5, LPGAT1cytosolOne of 2 routes
an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
1. acyl-CoA pool formation and breakdown
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 3 morecytosol
a 1-O-alkylglycerone 3-phosphateReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate
3. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)
Catalysed by GNPAT, AGPSperoxisomeOne of 2 routes
(9Z)-octadecen-1-olReach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. (9Z)-octadecenoyl-CoA + 2 NADPH + 2 H(+) = (9Z)-octadecen-1-ol + 2 NADP(+) + CoA
Catalysed by SCD, SCD5, FAR1cytosol
(9Z,12Z)-octadecadien-1-olReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, PLA2G15cytosolOne of 7 routes
3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (EPA)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CO2 + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol
(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (DPA)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + malonyl-CoA + H(+) = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
3-oxooctacosanyol-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
3. hexacosanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctacosanyol-CoA + CO2 + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol
3-oxotetracosanoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (behenic acid)
3. very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 16 morecytosolOne of 3 routes
3-oxohexacosanoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lignocerate)
3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 16 morecytosolOne of 3 routes
3-oxo-(11Z)-eicosenoyl-CoAReach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. (9Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-eicosenoyl-CoA + CO2 + CoA
Catalysed by SCD, SCD5, ELOVL7, ELOVL6 and 2 morecytosol
(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 13 morecytosol
(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (linolenate)
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 13 morecytosol
3-oxo-(13Z)-docosenoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
3. (11Z)-eicosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-docosenoyl-CoA + CO2 + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
3-oxo-(15Z)-tetracosenoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
3. (13Z)-docosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(15Z)-tetracosenoyl-CoA + CO2 + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
N-(9Z-octadecenoyl)-sphinganineReach from here →
1. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
2. sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)
3. sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)
Catalysed by SPTLC1, SPTLC2, SPTLC3, KDSR and 2 morecytosolOne of 2 routes
2-hydroxyhexadecanoyl-CoAReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. hexadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyhexadecanoyl-CoA + succinate + CO2
Catalysed by SCD, SCD5, PHYHcytosol
N-(15Z-tetracosenoyl)-sphinganineReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (nervonic acid)
3. (15Z)-tetracosenoyl-CoA + sphinganine = N-(15Z-tetracosenoyl)-sphinganine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes
an N-tetracosenoylsphinganineReach from here →
1. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
2. sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)
3. tetracosenoyl-CoA + sphinganine = an N-tetracosenoylsphinganine + CoA + H(+)
Catalysed by SPTLC1, SPTLC2, SPTLC3, KDSR and 1 morecytosol
N-hexacosenoylsphinganineReach from here →
1. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
2. sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)
3. hexacosenoyl-CoA + sphinganine = N-hexacosenoylsphinganine + CoA + H(+)
Catalysed by SPTLC1, SPTLC2, SPTLC3, KDSR and 1 morecytosol
N-tetracosanoyl-heptadecasphing-4-enineReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lignocerate)
3. heptadecasphing-4-enine + tetracosanoyl-CoA = N-tetracosanoyl-heptadecasphing-4-enine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
N-(2-hydroxytetracosenoyl)-sphinganineReach from here →
1. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
2. sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)
3. 2-hydroxytetracosenoyl-CoA + sphinganine = N-(2-hydroxytetracosenoyl)-sphinganine + CoA + H(+)
Catalysed by SPTLC1, SPTLC2, SPTLC3, KDSR and 1 morecytosol
(2E)-hexacosenoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
3. acyl-CoA oxidase (hexacosanoyl-CoA)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol, peroxisomeOne of 2 routes
3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
3. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
(6Z)-hexadecenoyl-CoAReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Catalysed by SCD, SCD5, FADS2cytosol
(2S)-2-aminobutanoateReach from here →
1. Palmitoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrixOne of 2 routes
N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. Palmitoyl-CoA hydrolase
2. acyl-CoA:sphingosine N-acyltransferase
3. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, Golgi apparatus
N-(tetracosenoyl)-sphing-4-enineReach from here →
1. Palmitoyl-CoA hydrolase
2. acyl-CoA:sphingosine N-acyltransferase
3. tetracosenoyl-CoA + sphing-4-enine = N-(tetracosenoyl)-sphing-4-enine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol, Golgi apparatus
1-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
1. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
3. sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 morecytosolOne of 2 routes
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by SCD, SCD5, AGPAT2, GPAT3 and 8 morecytosol