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Proteins/UNIPROT:Q96T53
Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity. In vitro also uses acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient..
Function from UniProtKB (Q96T53), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
14 statements
14 statements · 4 reference databases · Subject: MBOAT4 · Sources: Hetionet, Human-GEM, Reactome, Rhea
12 reactions
CHEBI:1146900+proton+MAM02538cCHEBI:15351+CHEBI:15650
Catalysed by LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or ZDHHC15 or ZDHHC2 or NAT9 or NAA40 or LPCAT3 or NAA60 or MBOAT7 and 20 more alternatives
4 names
Resolves to: MBOAT4
Human-GEM MAR01088CC BY 4.0Reference data
L-seryl-[protein]+acetyl-CoAO-acetyl-L-seryl-[protein]+coenzyme A(4-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59392CC BY 4.0Reference data
octanoyl-CoA+L-seryl-[protein]O-octanoyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59964CC BY 4.0Reference data
decanoyl-CoA+L-seryl-[protein]O-decanoyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59972CC BY 4.0Reference data
L-seryl-[protein]+a fatty acyl-CoAO-fatty acyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68272CC BY 4.0Reference data
L-seryl-[protein]+butanoyl-CoAO-butanoyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68276CC BY 4.0Reference data
CHEBI:57389+L-seryl-[protein]O-pentanoyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68280CC BY 4.0Reference data
hexanoyl-CoA+L-seryl-[protein]O-hexanoyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68284CC BY 4.0Reference data
CHEBI:78811+L-seryl-[protein]O-heptanoyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68288CC BY 4.0Reference data
CHEBI:76291+L-seryl-[protein]O-nonanoyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68292CC BY 4.0Reference data
L-seryl-[protein]+dodecanoyl-CoAO-dodecanoyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68296CC BY 4.0Reference data
L-seryl-[protein]+tetradecanoyl-CoAO-tetradecanoyl-L-seryl-[protein]+coenzyme A(4-)
Catalysed by MBOAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68300CC BY 4.0Reference data