Proteins/UNIPROT:Q6ICB0

DESI1

ProteinUNIPROT:Q6ICB0Desumoylating isopeptidase 1

Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5)..

Function from UniProtKB (Q6ICB0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

5 statements

5 statements · 2 reference databases · Subject: DESI1 · Sources: gene ontology, Hetionet

Order

FGF7 interacts with DESI1ProteinHetionet hetionet:interacts:2252-27351Inferred only
UBC interacts with DESI1ProteinHetionet hetionet:interacts:27351-7316Inferred only
DESI1 interacts with ZBTB46ProteinHetionet hetionet:interacts:140685-27351Inferred only
DESI1 regulates regulation of proteasomal ubiquitin-dependent protein catabolic processBiological processgene ontology Q6ICB0|GO:0032434Inferred only
CGRRF1 increases the expression of DESI1ProteinHetionet hetionet:regulates:10668-27351Inferred only

Reactions

1 reaction

S-hexadecanoyl-L-cysteinyl-[protein]+waterL-cysteinyl-[protein]+hexadecanoate+hydron
Catalysed by CLN5 or LYPLA1 or LYPLA2 or PPT1 or ABHD17B or LYPLAL1 or DESI1 or ABHD17C or CPT1C or ABHD17A or DESI2 or ABHD10
Reaction pageLeft to rightBalance undeterminable

Other names

8 names

Resolves to: DESI1

Also called: DeSI-1FAM152BPalmitoyl protein thioesterase DESI1Polyubiquitinated substrate transporterPOSTPPPDE peptidase domain-containing protein 2PPPDE2S-depalmitoylase DESI1

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