Proteins/UNIPROT:Q9BSY9

DESI2

ProteinUNIPROT:Q9BSY9Deubiquitinase DESI2

Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5)..

Function from UniProtKB (Q9BSY9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 2 reference databases · Subject: DESI2 · Sources: Bgee, Hetionet

Order

GRIN1 covaries with DESI2ProteinHetionet hetionet:covaries:2902-51029Inferred only
DESI2 covaries with NHLH2ProteinHetionet hetionet:covaries:4808-51029Inferred only
SOX4 covaries with DESI2ProteinHetionet hetionet:covaries:51029-6659Inferred only
WNT7B covaries with DESI2ProteinHetionet hetionet:covaries:51029-7477Inferred only
ZIC1 covaries with DESI2ProteinHetionet hetionet:covaries:51029-7545Inferred only
DESI2 is expressed in body of tongueAnatomyBgee ENSG00000121644Inferred only
DESI2 is expressed in lower lobe of lungAnatomyBgee ENSG00000121644Inferred only
DESI2 is expressed in male germ cellCell typeBgee ENSG00000121644Inferred only
DESI2 is expressed in nippleAnatomyBgee ENSG00000121644Inferred only
DESI2 is expressed in pericardiumAnatomyBgee ENSG00000121644Inferred only
DESI2 is expressed in pharyngeal mucosaAnatomyBgee ENSG00000121644Inferred only
DESI2 is expressed in secondary oocyteCell typeBgee ENSG00000121644Inferred only

Show the remaining 8

DESI2 is expressed in spermCell typeBgee ENSG00000121644Inferred only
DESI2 is expressed in superior surface of tongueAnatomyBgee ENSG00000121644Inferred only
DESI2 is expressed in tongueAnatomyBgee ENSG00000121644Inferred only
DESI2 is expressed in vena cavaAnatomyBgee ENSG00000121644Inferred only
UBC interacts with DESI2ProteinHetionet hetionet:interacts:51029-7316Inferred only
NT5C2 increases the expression of DESI2ProteinHetionet hetionet:regulates:22978-51029Inferred only
RRAGA decreases the expression of DESI2ProteinHetionet hetionet:regulates:10670-51029Inferred only
TM9SF3 increases the expression of DESI2ProteinHetionet hetionet:regulates:56889-51029Inferred only

Reactions

1 reaction

S-hexadecanoyl-L-cysteinyl-[protein]+waterL-cysteinyl-[protein]+hexadecanoate+hydron
Catalysed by CLN5 or LYPLA1 or LYPLA2 or PPT1 or ABHD17B or LYPLAL1 or DESI1 or ABHD17C or CPT1C or ABHD17A or DESI2 or ABHD10
Reaction pageLeft to rightBalance undeterminable

Other names

9 names

Resolves to: DESI2

Also called: C1orf121DeSI-2Desumoylating isopeptidase 2FAM152APalmitoyl protein thioesterase DESI2PPPDE peptidase domain-containing protein 1PPPDE1Protein FAM152AS-depalmitoylase DESI2

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