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Proteins/UNIPROT:Q96GS6

ABHD17A

Protein·UNIPROT:Q96GS6Alpha/beta hydrolase domain-containing protein 17A

Open in the graph

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6 (By similarity)..

Function from UniProtKB (Q96GS6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

43 statements

43 statements · 4 reference databases · Subject: ABHD17A · Sources: Bgee, gene ontology, Hetionet, Reactome

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STX10 covaries with ABHD17AProteinHetionet hetionet:covaries:81926-8677Inferred only
ABHD17A is expressed in Ammon's hornAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in amygdalaAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in anterior cingulate cortexAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in apex of heartAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in bloodAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in BrainAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in Brodmann (1909) area 9AnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in C1 segment of cervical spinal cordAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in caudate nucleusAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in cerebellar cortexAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in cerebellar hemisphereAnatomyBgee ENSG00000129968Inferred only

Show the remaining 31

ABHD17A is expressed in cerebellumAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in cerebral cortexAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in dorsolateral prefrontal cortexAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in granulocyteCell typeBgee ENSG00000129968Inferred only
ABHD17A is expressed in hindlimb stylopod muscleAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in hypothalamusAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in nucleus accumbensAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in putamenAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in right atrium auricular regionAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in right frontal lobeAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in right hemisphere of cerebellumAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in skin of legAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in spleenAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in substantia nigraAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in superior frontal gyrusAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in temporal lobeAnatomyBgee ENSG00000129968Inferred only
ABHD17A is expressed in zone of skinAnatomyBgee ENSG00000129968Inferred only
ABHD17A participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
ABHD17A participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
ABHD17A participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
ABHD17A participates in RAS processingPathwayReactome R-HSA-9648002Inferred only
ABHD17A participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ABHD17A regulates negative regulation of NLRP3 inflammasome complex assemblyBiological processgene ontology Q96GS6|GO:1900226Inferred only
ABHD17A regulates negative regulation of protein localization to microtubuleBiological processgene ontology Q96GS6|GO:1902817Inferred only
ABHD17A regulates negative regulation of skeletal muscle tissue regenerationBiological processgene ontology Q96GS6|GO:0043417Inferred only
ABHD17A regulates negative regulation of vesicle fusionBiological processgene ontology Q96GS6|GO:0031339Inferred only
ABHD17A regulates positive regulation of protein localization to endosomeBiological processgene ontology Q96GS6|GO:1905668Inferred only
ABHD17A regulates regulation of postsynapse organizationBiological processgene ontology Q96GS6|GO:0099175Inferred only
CSK decreases the expression of ABHD17AProteinHetionet hetionet:regulates:1445-81926Inferred only
MRPS16 increases the expression of ABHD17AProteinHetionet hetionet:regulates:51021-81926Inferred only
TPD52L2 increases the expression of ABHD17AProteinHetionet hetionet:regulates:7165-81926Inferred only

Reactions

1 reaction

S-hexadecanoyl-L-cysteinyl-[protein]+waterL-cysteinyl-[protein]+hexadecanoate+hydron
Catalysed by CLN5 or LYPLA1 or LYPLA2 or PPT1 or ABHD17B or LYPLAL1 or DESI1 or ABHD17C or CPT1C or ABHD17A or DESI2 or ABHD10
Reaction pageLeft to rightBalance undeterminable

Other names

3 names

Resolves to: ABHD17A

Also called: Abhydrolase domain-containing protein 17AC19orf27FAM108A1

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Rhea RHEA:19233CC BY 4.0Reference data