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Proteins/UNIPROT:Q5VWZ2
Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1. Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site..
Function from UniProtKB (Q5VWZ2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
15 statements
15 statements · 3 reference databases · Subject: LYPLAL1 · Sources: Bgee, gene ontology, Hetionet
1 reaction
1 name
Resolves to: LYPLAL1
Rhea RHEA:19233CC BY 4.0Reference data