Proteins/UNIPROT:Q5JVL4

EFHC1

ProteinUNIPROT:Q5JVL4

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death..

Function from UniProtKB (Q5JVL4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

30 statements

30 statements · 3 reference databases · Subject: EFHC1 · Sources: gene ontology, Hetionet, WikiPathways

Order

CCDC175 covaries with EFHC1ProteinHetionet hetionet:covaries:114327-729665Inferred only
CIMIP7 covaries with EFHC1ProteinHetionet hetionet:covaries:114327-646498Inferred only
EFHC1 covaries with DNHD1ProteinHetionet hetionet:covaries:114327-144132Inferred only
EFHC1 covaries with FAM227BProteinHetionet hetionet:covaries:114327-196951Inferred only
GATA1 covaries with EFHC1ProteinHetionet hetionet:covaries:114327-2623Inferred only
RIBC2 covaries with EFHC1ProteinHetionet hetionet:covaries:114327-26150Inferred only
EFHC1 covaries with TEKTL1ProteinHetionet hetionet:covaries:114327-126402Inferred only
EFHC1 covaries with TRIM45ProteinHetionet hetionet:covaries:114327-80263Inferred only
EFHC1 covaries with ZKSCAN7ProteinHetionet hetionet:covaries:114327-55888Inferred only
CACNA1E interacts with EFHC1ProteinHetionet hetionet:interacts:114327-777Inferred only
TEX11 interacts with EFHC1ProteinHetionet hetionet:interacts:114327-56159Inferred only
EFHC1 participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only

Show the remaining 18

EFHC1 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
EFHC1 regulates regulation of cell divisionBiological processgene ontology Q5JVL4|GO:0051302Inferred only
ACADS increases the expression of EFHC1ProteinHetionet hetionet:regulates:35-114327Inferred only
BAG3 increases the expression of EFHC1ProteinHetionet hetionet:regulates:9531-114327Inferred only
BIRC3 increases the expression of EFHC1ProteinHetionet hetionet:regulates:330-114327Inferred only
CCNA1 increases the expression of EFHC1ProteinHetionet hetionet:regulates:8900-114327Inferred only
CSNK1A1 increases the expression of EFHC1ProteinHetionet hetionet:regulates:1452-114327Inferred only
CSNK1G3 increases the expression of EFHC1ProteinHetionet hetionet:regulates:1456-114327Inferred only
DHCR7 increases the expression of EFHC1ProteinHetionet hetionet:regulates:1717-114327Inferred only
FOXJ1 increases the expression of EFHC1ProteinHetionet hetionet:regulates:2302-114327Inferred only
HDAC2 decreases the expression of EFHC1ProteinHetionet hetionet:regulates:3066-114327Inferred only
MRPS16 increases the expression of EFHC1ProteinHetionet hetionet:regulates:51021-114327Inferred only
PDPK1 increases the expression of EFHC1ProteinHetionet hetionet:regulates:5170-114327Inferred only
PISD increases the expression of EFHC1ProteinHetionet hetionet:regulates:23761-114327Inferred only
PPP2R3A increases the expression of EFHC1ProteinHetionet hetionet:regulates:5523-114327Inferred only
RNF166 increases the expression of EFHC1ProteinHetionet hetionet:regulates:115992-114327Inferred only
SQOR increases the expression of EFHC1ProteinHetionet hetionet:regulates:58472-114327Inferred only
STIL increases the expression of EFHC1ProteinHetionet hetionet:regulates:6491-114327Inferred only

Other names

2 names

Resolves to: EFHC1

Also called: EF-hand domain-containing protein 1Myoclonin-1

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