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Proteins/UNIPROT:Q8WZA1
Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity..
Function from UniProtKB (Q8WZA1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
8 rows
64 statements
64 statements · 7 reference databases · Subject: POMGNT1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
3 names
Resolves to: POMGNT1
Human-GEM MAR00925CC BY 4.0Reference data
3-O-(alpha-D-mannosyl)-L-threonyl-[protein]+UDP-N-acetyl-alpha-D-glucosamine3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein]+UDP+hydron
Catalysed by POMGNT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:54128CC BY 4.0Reference data