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Proteins/UNIPROT:Q86VD9
Alpha-1,2-mannosyltransferase that catalyzes the transfer of the fourth mannose, via an alpha-1,2 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed M4C) and participates in the twelfth step of the glycosylphosphatidylinositol-anchor biosynthesis (Probable). The presence of a fourth mannose in GPI is facultative, suggesting that it only exists in some tissues (Probable)..
Function from UniProtKB (Q86VD9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
18 statements
18 statements · 5 reference databases · Subject: PIGZ · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives
7 names
Resolves to: PIGZ
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR00765CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694g+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or POMGNT1 or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 16 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR00925CC BY 4.0Reference data
MAM01734r+MAM02020rMAM01733r+proton+MAM03748r
Catalysed by PIGZ
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR01399CC BY 4.0Reference data
MAM01734r+MAM02020rMAM01733r+proton+MAM03749r
Catalysed by PIGZ
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR01400CC BY 4.0Reference data
MAM01734r+MAM02430rMAM01733r+proton+MAM02432r
Catalysed by PIGZ
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR08389CC BY 4.0Reference data
MAM01734r+MAM01779rMAM01733r+proton+MAM02461r
Catalysed by PIGZ
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR08390CC BY 4.0Reference data
a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphateCHEBI:144090+a di-trans,poly-cis-dolichyl phosphate+hydron
Catalysed by PIGZ
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:61024CC BY 4.0Reference data