3-oxooctadecanoyl-CoA

Three steps

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 5 routes

• 2-hydroxyoctadecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2

  Catalysed by ACAA1, MYO5B, PHYHperoxisome, cytosol

• (15Z)-tetracosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 6 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 6 routes

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, GPAT3, LCLAT1 and 4 moreperoxisome, cytosol

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 2 moreperoxisome, cytosolOne of 2 routes

• 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, HADHA, ACADVL and 6 moreperoxisome, mitochondrial matrix

• 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by SCP2, HADHB, LPGAT1, TAFAZZIN

• 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, SCD, AGPAT1peroxisome, cytosol

• 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z)-hexadecenoyl-CoA = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by ACAA1, MYO5B, SCD, MBOAT1peroxisome, cytosol

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by ACAA1, MYO5B, MBOAT1, LPGAT1peroxisome, cytosol

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPGAT1peroxisome, cytosol

• 1-hexadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + (9Z)-octadecenoate + H(+)

  Catalysed by SCP2, HADHB, LPGAT1, PLA2G10 and 2 more

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPGAT1peroxisome, cytosol

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, LPGAT1peroxisome, cytosol

• nonadecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 4 routes

• 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoate + H(+)

  Catalysed by SCP2, HADHB, LCLAT1, LPCAT1 and 5 more

• 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by ACAA1, MYO5B, LCLAT1peroxisome, cytosol

• 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. octanoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT4peroxisome, cytosol

• 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. octanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
  3. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, HADHA, ACADVL and 2 moreperoxisome, mitochondrial matrix

• a 2,3-diacyl-sn-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, MOGAT1peroxisome, cytosol

• 1-hexadecanoyl-sn-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycerol + phosphate

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 3 moreperoxisome, cytosol

• 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerolReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
  3. 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)

  Catalysed by SCP2, HADHB, DGAT1, AWAT2 and 2 more

• 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
  3. 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACAA1, MYO5B, HADHA, ACADVL and 3 moreperoxisome, mitochondrial matrix

• 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, MOGAT1peroxisome, cytosol

• hexadecyl (9Z)-octadecenoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. formate dehydrogenase (palmitoyl-CoA)
  3. hexadecan-1-ol + (9Z)-octadecenoyl-CoA = hexadecyl (9Z)-octadecenoate + CoA

  Catalysed by ACAA1, MYO5B, FAR1, FAR2 and 2 moreperoxisome

• hexadecyl (9Z)-hexadecenoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. hexadecan-1-ol + (9Z)-hexadecenoyl-CoA = hexadecyl (9Z)-hexadecenoate + CoA

  Catalysed by ACAA1, MYO5B, SCD, AWAT1 and 1 moreperoxisome, cytosolOne of 2 routes

• hexadecyl octadecanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. formate dehydrogenase (palmitoyl-CoA)
  3. hexadecan-1-ol + octadecanoyl-CoA = hexadecyl octadecanoate + CoA

  Catalysed by ACAA1, MYO5B, FAR1, FAR2 and 2 moreperoxisomeOne of 2 routes

• 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerolReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
  3. 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)

  Catalysed by SCP2, HADHB, DGAT1, AWAT2 and 2 more

• (R)-2-hydroxyhexadecanoateReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)
  3. hexadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by SCP2, HADHB, ACOT7, ACOT8 and 16 more

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by SCP2, HADHB, LPCAT3, LPCAT1 and 1 moreOne of 3 routes

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by SCP2, HADHB, LPGAT1, PLA2G15One of 3 routes

• 1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by SCP2, HADHB, LPCAT3, LPCAT1 and 1 moreOne of 3 routes

• 2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by SCP2, HADHB, PRDX6, LPCAT3 and 6 moreOne of 10 routes

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by SCP2, HADHB, LPGAT1, PLA2G15One of 2 routes

• 1-O-alkyl-3-acylglycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, AWAT2peroxisome, cytosol

• dodecanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Activation of dodecanedioic acid

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Production of Sebacoylcarnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Production of Suberylcarnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 4 routes