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Reach

3-oxooctadecanoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

348 compounds within 3 steps: 2 in 1, 71 in 2, 275 in 3

Does it reach a compound?

Two steps

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by SCP2, HADHB, LPGAT1
1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SCP2, HADHB, LPCAT3, LPCAT1
1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by SCP2, HADHB, LCLAT1
1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SCP2, HADHB, LPCAT4
1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SCP2, HADHB, LPCAT4, LPCAT1
1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SCP2, HADHB, LPCAT1
1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SCP2, HADHB, LPCAT1
1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SCP2, HADHB, LPCAT1
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerolReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA
Catalysed by SCP2, HADHB, DGAT1, AWAT2 and 2 more
1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerolReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
Catalysed by SCP2, HADHB, DGAT1, AWAT2 and 1 more
hexadecyl hexadecanoateReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. hexadecan-1-ol + hexadecanoyl-CoA = hexadecyl hexadecanoate + CoA
Catalysed by SCP2, HADHB, DGAT1, AWAT1 and 1 more
1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SCP2, HADHB, MOGAT2, MOGAT1
2-hydroxyhexadecyl hexadecanoateReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA
Catalysed by SCP2, HADHB, DGAT1, AWAT2
1,2-O,O-dihexadecanoyl-1,2-hexadecanediolReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA
Catalysed by SCP2, HADHB, DGAT1
1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerolReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA
Catalysed by SCP2, HADHB, MOGAT3
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by SCP2, HADHB, LCLAT1
1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SCP2, HADHB, LPCAT4
1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SCP2, HADHB, LPCAT1
1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SCP2, HADHB, LPGAT1
hexadecanoateReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)
Catalysed by SCP2, HADHB, ACOT7, ACOT8 and 15 more
N-hexadecanoylhexadecasphinganineReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. hexadecasphinganine + hexadecanoyl-CoA = N-hexadecanoylhexadecasphinganine + CoA + H(+)
Catalysed by SCP2, HADHB, CERS6, CERS5
1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
2. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by SCP2, HADHB, HADHA
(7Z)-hexadecenoyl-CoAReach from here →
1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
2. stearoyl-CoA 9-desaturase (palmitoyl-CoA)
Catalysed by ACAA1, MYO5B, SCD, SCD5peroxisome, cytosol

Three steps

(S)-carnitineReach from here →
Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 256 routes
CHEBI:1307929Reach from here →
Catalysed by and 2 more

Page 2 of 7

ACAA1

, MYO5B

, SOAT2

, SOAT1

peroxisome, endoplasmic reticulum, lysosome

One of 2 routes

S-octanoyl-4'-phosphopantetheineReach from here →

acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
Beta Oxidation of Long Chain Fatty Acid
octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACAA1, MYO5B, ACADM, ACADS and 3 moreperoxisome, mitochondrial matrix

tetradecanoyl-4'-phosphopantetheineReach from here →

acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACAA1, MYO5B, HADHA, ACADVL and 3 moreperoxisome, mitochondrial matrix

an acyl-4'-phosphopantetheineReach from here →

acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
acyl-CoA pool formation and breakdown
an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACAA1, MYO5B, NUDT19, FITM2 and 1 moreperoxisome, cytosol

N-octadecanoylglycineReach from here →

acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
fatty-acyl-CoA synthase (N-C18:0CoA)
octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

Catalysed by ACAA1, MYO5B, GLYATL2peroxisome, cytosol

N-(9Z-hexadecenoyl)-glycineReach from here →

acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
(9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

Catalysed by ACAA1, MYO5B, SCD, GLYATL2peroxisome, cytosol

1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholineReach from here →

hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by SCP2, HADHB, PRDX6, LPCAT3 and 2 more

1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →

hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by SCP2, HADHB, PRDX6, LPCAT3 and 2 more

1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamineReach from here →

hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)

Catalysed by SCP2, HADHB, LPCAT3, LPCAT1 and 3 more

1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamineReach from here →

hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)

Catalysed by SCP2, HADHB, LPCAT3, LPCAT1 and 3 more

2-hydroxyoctanoyl-CoAReach from here →

acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
Beta Oxidation of Long Chain Fatty Acid
octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2

Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

2-hydroxytetradecanoyl-CoAReach from here →

acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2