3-oxoeicosanoyl-CoA

Three steps

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by ACAA1, MYO5B, LPGAT1, PLA2G15peroxisomeOne of 3 routes

• 1-octadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by ACAA1, MYO5B, LPGAT1, PLA2G15peroxisomeOne of 2 routes

• 2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-octadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by ACAA1, MYO5B, LPCAT3, PLA2G4EperoxisomeOne of 2 routes

• 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine

  Catalysed by ACAA1, MYO5B, LPGAT1, PLA2G15peroxisomeOne of 2 routes

• 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by ACAA1, MYO5B, LPGAT1, PLA2G15peroxisome

• 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
  3. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPGAT1peroxisome

• 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPGAT1peroxisome

• 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by ACAA1, MYO5B, LPGAT1, PLA2G15peroxisome

• 1-O-alkyl-3-acylglycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, AWAT2peroxisome, cytosol

• dodecanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. Activation of dodecanedioic acid

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. Production of Sebacoylcarnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. Production of Suberylcarnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 6 routes

• 3-oxo-(13Z)-eicosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
  3. (11Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA

  Catalysed by ACAA1, MYO5B, SCD, ELOVL5peroxisome, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 6 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol

• hexadecanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 2 routes

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)
  3. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 3 moreperoxisome, cytosol

• 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)
  3. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 3 moreperoxisome, cytosol

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)
  3. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 3 moreperoxisome, cytosol

• pristanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. fatty-acid-CoA ligase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT1peroxisome, cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT2, LPCAT1peroxisome, cytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT4peroxisome, cytosol

• 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, SCD, SCD5 and 3 moreperoxisome

• 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, SCD, SCD5 and 1 moreperoxisome

• undecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 9 moreperoxisome, cytosolOne of 3 routes

• (2E,9Z)-octadecadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
  3. medium-chain acyl-CoA dehydrogenase (oleoyl-CoA)

  Catalysed by ACAA1, MYO5B, SCD, ACADM and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 4 routes

• N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-octadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by ACAA1, MYO5B, LPCAT3, PLA2G4Eperoxisome

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine

  Catalysed by ACAA1, MYO5B, LPGAT1, PTDSS2peroxisome

• 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-(1Z-octadecenyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by ACAA1, MYO5B, LPGAT1, TMEM164peroxisome

• hexadecanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by ACAA1, MYO5B, LPCAT3, PLAAT3peroxisome

• 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by ACAA1, MYO5B, SCD, SCD5 and 1 moreperoxisome

• (5Z)-tetradecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 9 routes

• O-(9Z)-octadecenoyl-(R)-carnitineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA

  Catalysed by ACAA1, MYO5B, SCD, SCD5 and 1 moreperoxisome

• beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
  3. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine

  Catalysed by ACAA1, MYO5B, CERS1, TLCD3B and 3 moreperoxisome

• (3E)-decenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 7 moreperoxisome, cytosol, mitochondrial matrix

• 1-decanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. 1-decanoylglycerol + (9Z)-octadecenoyl-CoA = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACAA1, MYO5B, SCD, SCD5 and 1 moreperoxisome

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, GLYATL1B, GLYATL1peroxisome, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 10 routes

• cholesteryl (11Z)-octadecenoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
  3. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA

  Catalysed by ACAA1, MYO5B, SCD, SOAT1peroxisome, cytosol

• tricosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. Stearoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxoeicosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by ACAA1, MYO5B, SCP2, ACAA2 and 1 moreperoxisome, cytosol