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Proteins/UNIPROT:Q5U3C3
Positive regulator of ferroptosis. Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis. Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death..
Function from UniProtKB (Q5U3C3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 3 reference databases · Subject: TMEM164 · Sources: gene ontology, Hetionet, Rhea
1 reaction
1-(1Z-octadecenyl)-sn-glycero-3-phosphoethanolamine+1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+1-octadecanoyl-sn-glycero-3-phosphocholine
Catalysed by TMEM164
Reaction pageLeft to rightBalanced
Rhea RHEA:79431CC BY 4.0Reference data
2 names
Resolves to: TMEM164