spermidine
362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API
603 compounds within 3 steps: 14 in 1, 119 in 2, 470 in 3
Two steps
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 4 routes
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 4 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 3 routes
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 4 routes
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 4 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by SAT1, SAT2, CRAT, CROTcytosol, peroxisomeOne of 3 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by SAT1, SAT2, ACAA1, HSD17B4 and 2 morecytosol, peroxisome
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 2 routes
Catalysed by SAT1, SAT2, ACSM4, ACSM1 and 4 morecytosolOne of 3 routes
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by SAT1, SAT2, ACADM, ECHS1 and 2 morecytosol, mitochondrial matrix
- diamine N-acetyltransferase (N1-acetylspermidine)
- acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by SAT1, SAT2, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrix
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 4 routes
Three steps
- N8-acetylspermidine to spermidine conversion
- N(8)-acetylspermidine + H2O = spermidine + acetate
- transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)
Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes