itaconyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

601 compounds within 3 steps: 6 in 1, 116 in 2, 479 in 3

Two steps

(R)-methylmalonyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)
Catalysed by SUCLG1, SUCLG2, SUCLA2, ALDH6A1mitochondrial matrixOne of 2 routes
(S)-methylmalonyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. (S)-methylmalonyl-CoA hydrolase
Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrix
3'-dephospho-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. acid phosphatase 2, lysosomal (CoA)
Catalysed by SUCLG1, SUCLG2, SUCLA2, ACP2mitochondrial matrix, lysosomeOne of 2 routes
(2E)-dodecenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. (2E)-dodecenoyl-CoA formation
Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrixOne of 3 routes
(2E)-butenoyl-CoAReach from here →
1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
2. glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)
Catalysed by SUGCT, GCDHmitochondrial matrixOne of 2 routes
4,8,12-trimethyltridecanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)
Catalysed by SUCLG1, SUCLG2, SUCLA2, ACAA1 and 1 moremitochondrial matrix, peroxisomeOne of 2 routes
(2E)-glutaconyl-CoAReach from here →
1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
2. glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2
Catalysed by SUGCT, ACOX1
(6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes
butanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. Butanoate:CoA ligase (AMP-forming)
Catalysed by SUCLG1, SUCLG2, SUCLA2, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 9 routes
dodecanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 9 routes
eicosanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 12 routes
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 13 routes
tetradecanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (myristic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 11 routes
octanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
Catalysed by SUCLG1, SUCLG2, SUCLA2, CROTmitochondrial matrixOne of 20 routes
phytanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. phytanate-CoA ligase
Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrix, cytosolOne of 5 routes
octadecanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (stearate)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 6 moremitochondrial matrix, cytosolOne of 15 routes
sphing-4-enineReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. acyl-CoA:sphingosine N-acyltransferase
Catalysed by SUCLG1, SUCLG2, SUCLA2, ASAH1 and 3 moremitochondrial matrix, Golgi apparatusOne of 2 routes
spermidineReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. diamine N-acetyltransferase (N1-acetylspermidine)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SAT1 and 1 moremitochondrial matrix, cytosolOne of 3 routes
L-methionineReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. N-acetylglutamate synthase (N-acetylmethionine)
Catalysed by SUCLG1, SUCLG2, SUCLA2, NAGSmitochondrial matrix
L-alanineReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrix
L-asparagineReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. N-acetylglutamate synthase (N-acetyl-L-asparagine)
Catalysed by SUCLG1, SUCLG2, SUCLA2, NAGSmitochondrial matrix
L,L-cystathionineReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
Catalysed by SUCLG1, SUCLG2, SUCLA2, NAGSmitochondrial matrix
an acyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. acyl-CoA:sphingosine N-acyltransferase
Catalysed by SUCLG1, SUCLG2, SUCLA2, ASAH1 and 3 moremitochondrial matrix, Golgi apparatusOne of 2 routes
(3Z)-dodecenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)
Catalysed by SUCLG1, SUCLG2, SUCLA2, HADHA and 2 moremitochondrial matrixOne of 3 routes
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 1 moremitochondrial matrix, endoplasmic reticulumOne of 3 routes
deoxycholoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 1 moremitochondrial matrix, cytosolOne of 4 routes
decanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. medium-chain acyl-CoA ligase (decanoic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 7 routes
(2E)-hexadecenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. Carnitine O-Palmitoyltransferase
Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 4 routes
(9Z)-hexadecenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 11 routes
3-hydroxyisovaleryl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)
Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 1 moremitochondrial matrix, cytosol
CHEBI:63544Reach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (adrenic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes
hexacosanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes
tetracosanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (lignocerate)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 10 routes
docosanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (behenic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 9 routes
(2E)-octadecenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. Carnitine O-Palmitoyltransferase
Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 3 routes
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (stearidonic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 8 routes
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (EPA)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 9 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (DPA)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes
(9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (linolenate)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes
(13Z)-docosenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes
(11Z)-eicosenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 4 routes
(15Z)-tetracosenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (nervonic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes
(17Z)-hexacosenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (ximenic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 4 routes
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes