a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine

Three steps

• eicosanoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 6 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (linoleate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 5 routes

• tetradecanoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 4 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular space

• octadecanoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, extracellular spaceOne of 6 routes

• prostaglandin H2Reach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. prostaglandin-endoperoxide synthase (arachidonate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular spaceOne of 3 routes

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular space

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular space

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• leukotriene A4Reach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Linoleate:oxygen 13-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular space

• (R)-2-hydroxyoctadecanoateReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
  2. triacylglycerol acylhydrolase
  3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol

  Catalysed by TMEM68, LPL, SGMS1, SGMS2extracellular spaceOne of 6 routes

• sphinganineReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + H2O = sphinganine + a fatty acid

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
  2. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
  3. a 1,2-diacylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a triacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by TMEM68, LIPA, PNPLA4, LIPN and 1 more

• an acyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. acyl-CoA pool formation and breakdown

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 14 morecytosol, extracellular space

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
  2. triacylglycerol acylhydrolase
  3. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)

  Catalysed by TMEM68, LPL, DGKI, DGKA and 9 moreextracellular space

• CDP-cholineReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  2. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H(+)
  3. phosphocholine + CTP + H(+) = CDP-choline + diphosphate

  Catalysed by PLA2G6, PLA2G4A, PLA2G4F, PLB1 and 5 moreOne of 2 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular space

• (9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. linoleate:oxygen 9-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 14 morecytosol, extracellular space

• (2E)-hexadecenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Long-Chain-Fatty-Acid-Coa Ligase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, extracellular space, endoplasmic reticulumOne of 2 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 5 routes

• CHEBI:63544Reach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 2 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. cytochrome P450 (arachidonate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space, endoplasmic reticulumOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by PLA2G6, PLA2G4A, PLA2G4F, PLB1 and 4 moreOne of 2 routes

• a triacyl-sn-glycerolReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
  2. triacylglycerol acylhydrolase
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by TMEM68, LPL, DGAT1, MOGAT2 and 3 moreextracellular space

• a 1-acyl-sn-glycerolReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  2. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
  3. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)

  Catalysed by PLA2G6, PLA2G4A, PLA2G4F, PLB1 and 3 more

• hexacosanoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 3 routes

• tetracosanoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 6 routes

• docosanoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 4 routes

• N-hexadecanoyl-(4R)-hydroxysphinganineReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
  2. triacylglycerol acylhydrolase
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by TMEM68, LPL, SGMS1, SGMS2extracellular space

• N-hexadecanoylsphinganineReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
  2. triacylglycerol acylhydrolase
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by TMEM68, LPL, SGMS1, SGMS2extracellular space

• an N-acylsphinganine-1-phosphocholineReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol

• a 1-organyl-2-acetyl-sn-glycero-3-phospholipidReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  2. a 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  3. a 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = a 1-organyl-2-acetyl-sn-glycero-3-phospholipid + a 1-O-alkyl-sn-glycero-3-phosphocholine

  Catalysed by PLA2G6, PLA2G4A, PLA2G4F, PLB1 and 5 more

• (2E)-octadecenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. fatty-acid-CoA ligase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• N-dodecanoylsphing-4-enineReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 morecytosol, extracellular space

• N-tetradecanoylsphing-4-enineReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular space

• N-octadecanoylsphing-4-enineReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular space

• a 1-O-alkylglycerone 3-phosphateReach from here →
  1. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  2. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  3. a 1-O-alkylglycerone 3-phosphate + NADPH + H(+) = a 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)

  Catalysed by PLA2G6, PLA2G4A, PLA2G4F, PLB1 and 5 more

• (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (7Z,10Z,13Z,16Z)-docosatetraenoate + ATP + CoA = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 3 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 2 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 2 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 2 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 2 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 2 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 2 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. plasmanylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 3 routes