(6R)-5,10-methylenetetrahydrofolic acid

Three steps

• glutathioneReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by SHMT1, GSScytosol

• L-alanineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC3A2, SLC7A5, SLC7A10cytosol, extracellular spaceOne of 13 routes

• leukotriene C4Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. leukotriene C4 hydrolysis

  Catalysed by SHMT1cytosol

• L-asparagineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by SHMT1cytosol, extracellular spaceOne of 7 routes

• L-phenylalanineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5cytosol, extracellular spaceOne of 13 routes

• L-homocysteineReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by MTHFR, MTR, BHMT2cytosol

• S-methyl-L-methionineReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by MTHFR, MTR, BHMT2cytosol

• L-tyrosineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by SHMT1, AADATcytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SHMT1, AGXT2cytosol

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SHMT1, ATIC, ADSLcytosolOne of 2 routes

• 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate

  Catalysed by SHMT1, ATICcytosolOne of 3 routes

• L-methionine (S)-S-oxideReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by MTHFR, MTR, MSRAcytosol

• L-methionine (R)-S-oxideReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by MTHFR, MTR, MSRB3, MSRB1 and 1 morecytosol

• N-formimidoyl-L-glutamateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by SHMT1, FTCDcytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SHMT1, GLYATL2cytosolOne of 2 routes

• N-benzoylglycineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by SHMT1cytosol, mitochondrial matrixOne of 2 routes

• 3',3'-cGAMPReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

  Catalysed by SHMT1, ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

• (2S)-2-aminobutanoateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by SHMT1, AGXT2cytosol

• glycodeoxycholateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SHMT1cytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by SHMT1, GLYATL2cytosol

• N-eicosanoylglycinateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by SHMT1, BAATcytosol

• N-docosanoylglycineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SHMT1, BAATcytosol

• N-hexacosanoylglycineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SHMT1, BAATcytosol