D-glucosyl-N-acylsphingosine

Three steps

• dTMPReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. dATP:D-glucose 6-phosphotransferase
  3. deoxythymidylate kinase (dADP)

  Catalysed by GBA1, GBA3, GBA2, HK1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:63544Reach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• 1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 4 morecytosol, Golgi apparatus

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 7 morecytosol, Golgi apparatusOne of 2 routes

• a triacyl-sn-glycerolReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 9 morecytosol, Golgi apparatusOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 6 morecytosol, Golgi apparatus

• hexacosanoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• tetracosanoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• docosanoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• N-hexadecanoyl-(4R)-hydroxysphinganineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by GBA1, GBA3, GBA2, SGMS1 and 1 morecytosol, Golgi apparatus

• N-hexadecanoylsphinganineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by GBA1, GBA3, GBA2, SGMS1 and 1 morecytosol, Golgi apparatus

• (22R)-hydroxycholesterolReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (22R)-hydroxycholesterol + 2 oxidized [adrenodoxin] + H2O

  Catalysed by GBA1, GBA3, GBA2, CYP11A1cytosolOne of 2 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• a ganglioside GM2 (d18:1(4E))Reach from here →
  1. glucosylceramide pool to LacCer pool conversion
  2. beta-1,4-N-acetyl-galactosaminyltransferase (LacCer pool)
  3. lactosylceramide alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)

  Catalysed by ALG1L2, B4GALT5, B3GALT2, B4GALT3 and 34 moreendoplasmic reticulum, cytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. N-Acylsphingosine amidohydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GBA1, GBA3, GBA2, ASAH1cytosol, lysosome, extracellular spaceOne of 12 routes

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)

  Catalysed by GBA1, GBA3, GBA2, SGMS2 and 1 morecytosol

• N-dodecanoylsphing-4-enineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 4 morecytosol, Golgi apparatusOne of 3 routes

• N-tetradecanoylsphing-4-enineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• N-hexadecanoylsphing-4-enineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 7 morecytosol, Golgi apparatusOne of 3 routes

• N-octadecanoylsphing-4-enineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 7 morecytosol, Golgi apparatusOne of 3 routes

• N-eicosanoyl-sphing-4-enineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 5 morecytosol, Golgi apparatus

• N-tetracosanoyl-sphing-4-enineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 4 morecytosol, Golgi apparatus

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by GBA1, GBA3, GBA2, LCATcytosolOne of 9 routes

• 1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by GBA1, GBA3, GBA2, SGMS1 and 1 morecytosol, Golgi apparatusOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (13Z)-docosenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (11Z)-eicosenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (15Z)-tetracosenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (17Z)-hexacosenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• heptadecanoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (9Z)-heptadecenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatusOne of 2 routes

• N-(tetracosenoyl)-sphing-4-enineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. tetracosenoyl-CoA + sphing-4-enine = N-(tetracosenoyl)-sphing-4-enine + CoA + H(+)

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 4 morecytosol, Golgi apparatus

• nonadecanoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• a 2,3-diacyl-sn-glycerolReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 5 morecytosol, Golgi apparatus

• an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enineReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase
  3. 3'-Phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase

  Catalysed by GBA1, GBA3, GBA2, UGT8 and 1 morecytosol, lysosomeOne of 2 routes

• 1-O-alkyl-3-acylglycerolReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 5 morecytosol, Golgi apparatus

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (13Z)-eicosenoyl-CoAReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 morecytosol, Golgi apparatus

• (25R)-cholest-5-ene-3beta,26-diolReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (25R)-cholest-5-ene-3beta,26-diol + 2 oxidized [adrenodoxin] + H2O

  Catalysed by GBA1, GBA3, GBA2, CYP27A1cytosol

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphateReach from here →
  1. D-Glucosyl-N-acylsphingosine glucohydrolase
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(out) + cholesterol(in) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(in) + cholesterol(out)

  Catalysed by GBA1, GBA3, GBA2, OSBPL2cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes