3,3',5-triiodo-L-thyronine sulfate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

237 compounds within 3 steps: 4 in 1, 44 in 2, 189 in 3

Three steps

kynurenateReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
Catalysed by STS, SLC25A35, SLC25A34, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
S-sulfanyl-L-cysteineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine
Catalysed by DIO1, MOCOS, CARS2
phosphoenolpyruvateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
Catalysed by DIO1, D2HGDH, PCK1, PCK2
D-glucosamineReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
Catalysed by STS, SGSHcytosol
S-sulfanylglutathioneReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
Catalysed by STS, SLC25A14, SLC25A30, ETHE1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (R)-4'-phosphopantothenate:L-cysteine ligase
Catalysed by DIO1, MOCOS, PPCScytosolOne of 4 routes
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
4-aminobutanoateReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
Catalysed by STS, SLC26A6, SLC6A12cytosol, extracellular spaceOne of 4 routes
3-iodo-L-tyrosineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. iodide:hydrogen-peroxide oxidoreductase
3. thyroid peroxidase (iodine)
Catalysed by DIO1, TPOcytosolOne of 2 routes
prostaglandin E2Reach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
N-benzoylglycineReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
3-sulfino-L-alanineReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
Catalysed by STS, SLC25A14, SLC25A30, SLC25A12 and 1 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 6 routes
an all-trans-retinyl esterReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. Lecithin Retinol Acyltransferase
Catalysed by DIO1, RETSAT, LRATcytosolOne of 4 routes
ubiquinol-10Reach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
Catalysed by STS, SLC25A14, SLC25A30, SQORcytosol, inner side of the membrane, outer side of the membrane
a 2,3-saturated acyl-CoAReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
Catalysed by DIO1, AIFM1, PYROXD1, ACAD10One of 2 routes
all-trans-retinyl 9Z-octadecenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by DIO1, RETSAT, PNPLA4, PNPLA2
di-(9Z)-octadecenoylglycerolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by DIO1, RETSAT, PNPLA4, PNPLA2
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by DIO1, RETSAT, LRAT
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS1 and 1 more
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS1 and 1 more
9-cis-retinolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol binding protein (retinol)
Catalysed by DIO1, RETSAT, RBP1, RBP2cytosolOne of 2 routes
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
thio-Mo-molybdopterinReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, MOCOSOne of 3 routes
2-glyceryl-prostaglandin H2Reach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by STS, CYP3A7cytosol
prostaglandin H1Reach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS1 and 1 more