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Proteins/UNIPROT:B2RXH2
Histone demethylase that demethylates trimethylated 'Lys-9' of histone H3 into monomethylated form, thereby playing a central role in histone code. Also demethylates trimethylated 'Lys-56' of histone H3 (H3K9me3) to generate the monomethylated state (H3K56me1)..
Function from UniProtKB (B2RXH2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 statements
6 statements · 4 reference databases · Subject: KDM4E · Sources: gene ontology, Reactome, Rhea, UniProt
5 reactions
N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3]+2-oxoglutarate(2-)+dioxygenN(6)-methyl-L-lysyl(9)-[histone H3]+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by KDM4E or KDM1A or PHF2 or PHF8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60192CC BY 4.0Reference data
N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]+22-oxoglutarate(2-)
5 names
Resolves to: KDM4E
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60200CC BY 4.0Reference data
N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]+2-oxoglutarate(2-)+dioxygenN(6),N(6)-dimethyl-L-lysyl(9)-[histone H3]+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by KDM4E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60204CC BY 4.0Reference data
N(6),N(6),N(6)-trimethyl-L-lysyl(56)-[histone H3]+2-oxoglutarate(2-)+dioxygenN(6),N(6)-dimethyl-L-lysyl(56)-[histone H3]+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by KDM4E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:85927CC BY 4.0Reference data
N(6),N(6)-dimethyl-L-lysyl(56)-[histone H3]+2-oxoglutarate(2-)+dioxygenN(6)-methyl-L-lysyl(56)-[histone H3]+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by KDM4E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:85931CC BY 4.0Reference data